Determinants and Temporal Trends of Perfluoroalkyl Substances in Pregnant Women: The Hokkaido Study on Environment and Children's Health

International Journal of Environmental Research and Public Health
Meng-Shan TsaiReiko Kishi

Abstract

Perfluoroalkyl substances (PFAS) are persistent bio-accumulative chemicals that impact the health of pregnant women and their children. PFAS derive from environmental and consumer products, which depend on human lifestyle, socioeconomic characteristics, and time variation. Here, we aimed to explore the temporal trends of PFAS in pregnant women and the characteristics related to maternal PFAS concentration. Our study is part of the Hokkaido Study on Environment and Children's Health, the Hokkaido large-scale cohort that recruited pregnant women between 2003 and 2011. Blood samples were acquired from pregnant women during the third trimester to measure PFAS and cotinine concentrations. Maternal basic information was collected with a baseline structured questionnaire. Eleven PFAS were measured from 2123 samples with ultra-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry. Eight PFAS were above 80% detection rate and were included in the final analysis. We used multivariable linear regression to analyze the association of pregnant women characteristics with the levels of eight PFAS. The temporal trend of PFAS was observed in two periods (August 2003 to January 2006 and February 2006 to July 2...Continue Reading

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Citations

Jul 10, 2020·Environmental Health : a Global Access Science Source·Christel NielsenKristina Jakobsson
Jun 27, 2019·Scientific Reports·Sverre WikströmCarl-Gustaf Bornehag
Nov 5, 2020·International Journal of Environmental Research and Public Health·Marco BonatoGianfranco Santovito
Jun 11, 2021·The Journal of Obstetrics and Gynaecology Research·Aline de Souza Espindola SantosCarmen Ildes Rodrigues Froes Asmus

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS
PFUnDA

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