Determinants of a good perinatal outcome in 588 pregnancies in women with type 1 diabetes

Diabetes & Metabolism
J LepercqJ Timsit

Abstract

This study assessed pregnancy outcomes in women with type 1 diabetes (T1D) over the last 15 years and identified modifiable factors associated with good perinatal outcomes. Pregnancy outcomes were prospectively assessed in this cohort study of 588 singleton pregnancies (441 women) managed by standardized care from 2000 to 2014. A good perinatal outcome was defined as the uncomplicated delivery of a normally formed, non-macrosomic, full-term infant with no neonatal morbidity. Factors associated with good perinatal outcomes were identified by logistic regression. The rate of severe congenital malformations was 1.5%, and 0.7% for perinatal mortality. The most frequent perinatal complications were macrosomia (41%), preterm delivery (16%) and neonatal hypoglycaemia (11%). Shoulder dystocia occurred in 2.6% of cases, but without sequelae. Perinatal outcomes were good in 254 (44%) pregnancies, and were associated with lower maternal HbA1c values at delivery [adjusted odds ratio (aOR): 2.78, 95% CI: 2.04-3.70, for each 1% (11mmol/mol) absolute decrease], lower gestational weight gains (aOR: 1.06, 95% CI: 1.02-1.10) and absence of preeclampsia (aOR: 2.63, 95% CI: 1.09-6.25). The relationship between HbA1c at delivery and a good perinata...Continue Reading

References

Jul 20, 1999·American Journal of Obstetrics and Gynecology·E ReyA Bonin
Apr 30, 2003·Diabetes Care·Jeannet LauenborgPeter Damm
Oct 28, 2003·Diabetes Care·Pierre BoulotUNKNOWN Diabetes and Pregnancy Group, France
Nov 25, 2004·Diabetes Care·Dorte M JensenHenning Beck-Nielsen
May 22, 2007·Lancet·Lisa M AskieUNKNOWN PARIS Collaborative Group
Apr 17, 2008·Journal of Diabetes and Its Complications·Pia EkbomElisabeth R Mathiesen
Apr 23, 2010·Obstetrics and Gynecology·Jacques LepercqJosé Timsit
Feb 7, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·M PerssonM Norman
Sep 12, 2012·Nature Reviews. Endocrinology·Lene RingholmPeter Damm
Apr 11, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Miriam ColstrupLene Ringholm
May 3, 2013·Obstetrics and Gynecology·Grégoire MiailheJacques Lepercq
May 9, 2014·Obstetrics and Gynecology·Christina M ScifresJanet M Catov
Nov 5, 2014·Diabetes Care·Michael J A MareshUNKNOWN Diabetes and Pre-eclampsia Intervention Trial Study Group
Dec 30, 2014·Diabetes Care·UNKNOWN American Diabetes Association
Jan 29, 2016·The Journal of Clinical Endocrinology and Metabolism·Lisa A OwensFidelma Dunne

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Citations

Sep 25, 2021·Archives of Gynecology and Obstetrics·Friederike WeschenfelderTanja Groten
Oct 26, 2021·The Journal of Clinical Endocrinology and Metabolism·Madleen LemaitreAnne Vambergue

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