Determinants of airway responsiveness to adenosine 5'-monophosphate in school-age children with asthma

Pediatric Pulmonology
Arzu Bakirtas, Ipek Turktas

Abstract

Airway responsiveness to adenosine 5'-monophosphate (AMP) is more specific than that to direct stimuli for asthma diagnosis and response to treatment, but is not detected in all patients with asthma. This study was planned to determine predictive factors for responsiveness to AMP in asthmatic children between 7-16 years old. We performed a retrospective analysis of data from 71 asthmatic children who were challenged by AMP in our department. All children were characterized by skin-prick and lung function tests and bronchial challenge with AMP. Data on simultaneous methacholine challenge tests were available for 46 children, 34 of whom were also challenged with a third stimulus, exercise. Potential demographic factors for responsiveness to AMP were assessed by logistic regression analysis within the study group. The proportion of school-age children with asthma responsive to AMP was 39.4%. The geometric mean provocative concentration of AMP causing a 20% decrease in forced expiratory volume in 1 sec (PC20AMP) was 20.50 mg/ml (range, 0.31-377 mg/ml). There were no significant differences either in response to methacholine below 16 mg/ml (P = 0.66) or in PC20 methacholine level (P = 0.075) when we compared AMP-responsive and -nonr...Continue Reading

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Citations

Mar 24, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jose A Castro-RodriguezLuis Garcia-Marcos
Aug 24, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Arzu Bakirtas, Ipek Turktas
Feb 24, 2011·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Dong I SuhYoung Y Koh
Jan 25, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D I SuhY Y Koh
Apr 21, 2011·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Luis MansoJoaquín Sastre
Nov 8, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Mustafa ArgaIpek Turktas
Nov 2, 2012·Allergy, Asthma & Immunology Research·Sung Han KangSoo-Jong Hong
Jul 3, 2013·Allergy, Asthma & Immunology Research·Dong In Suh, Young Yull Koh
Mar 7, 2020·Pediatric Allergy, Immunology, and Pulmonology·Gabriel LevinAmihai Rottensctreich

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