Determinants of albumin concentration in hemodialysis patients

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
George A KaysenT A Depner

Abstract

Hypoalbuminemia predicts mortality in hemodialysis patients with end-stage renal disease and is assumed to result from malnutrition. To investigate a possible alternative cause, we evaluated the relationships between serum albumin (Salb) and serum levels of two positive acute-phase proteins: C-reactive protein (CRP) and serum amyloid A (SAA). We also examined the relationship between Salb and dialysis dose delivered (Kt/V) and normalized protein catabolic rate (PCRn) measured during 3 consecutive months in a group of 115 patients. Serum albumin was measured monthly for 5 months. SAA levels were not increased in the majority of patients, despite its low molecular weight (8 kd), and predialysis concentrations were independent of residual renal function, compatible with a nonrenal site of metabolism. Both CRP and SAA levels correlated negatively with Salb both by linear regression and by multiple regression analysis (P < 0.001). CRP correlated with fibrinogen (P < 0.005). Salb also correlated positively with PCRn (P = 0.001), but not with Kt/V. The Kt/V did not correlate with PCRn. While CRP and SAA correlated with one another, neither variable correlated with PCRn. When either SAA or CRP was high, Salb was low regardless of PCRn....Continue Reading

References

Jan 1, 1975·The American Journal of Medicine·T Maack
Jul 1, 1991·The Japanese Journal of Surgery·T SaitoM Kobayashi
May 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E G Lowrie, N L Lew
Nov 1, 1986·The Journal of Clinical Investigation·D H PerlmutterH R Colten
May 1, 1989·The Journal of Clinical Investigation·G A KaysenF N Hutchison
Jun 1, 1987·Inflammation·G F TuG Howlett
Jun 1, 1987·The Journal of Clinical Investigation·H J MoshageS H Yap
Feb 1, 1986·Kidney International·G A KaysenF N Hutchison
Apr 1, 1971·The Journal of Clinical Investigation·R P MogielnickiW Strober
Sep 1, 1983·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·J C JamiesonK Ham
Apr 1, 1984·The Journal of Clinical Investigation·M A ZernD A Shafritz
Jan 1, 1984·Kidney International·G A Kaysen, P Y Schoenfeld
Aug 1, 1995·Kidney International·G A KaysenT A Depner
Jul 1, 1994·Advances in Renal Replacement Therapy·D W Windus
Feb 1, 1995·Kidney International·A A KaplanC W Graeber
Mar 1, 1994·Journal of the American Society of Nephrology : JASN·P Zaoui, R M Hakim
Jun 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J P CapelliM A Torres
Jul 1, 1993·Kidney International·K IsekiK Fukiyama
Jan 1, 1996·Journal of the American Society of Nephrology : JASN·D E Uehlinger

❮ Previous
Next ❯

Citations

Nov 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·W Koenig, C Wanner
May 26, 2001·Annual Review of Nutrition·R Mehrotra, J D Kopple
Jan 14, 2005·The International Journal of Artificial Organs·S UrsoG Battaglia
Mar 16, 2006·The Journal of Medical Investigation : JMI·Miho KogirimaShigeru Yamamoto
Nov 10, 2007·Seminars in Dialysis·Ray K WanAlan G Jardine
Jan 10, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Volker WizemannDaniele Marcelli
Jul 8, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Rebecca PellicanoPeter G Kerr
Dec 18, 2013·Journal of Renal Care·Türkay AkbaşEmel Akoğlu
Jan 11, 2016·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Koji KawahitoYoshio Misawa
Jun 29, 2018·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Soki Kurumisawa, Koji Kawahito
May 7, 2019·Expert Review of Cardiovascular Therapy·Mohan SatishDevendra K Agrawal
Feb 24, 2001·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·M TonelliN Muirhead
Sep 17, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·W D KloppenburgR M Huisman
Feb 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·W E SchoutenM J Nubé
Apr 16, 2002·Seminars in Dialysis·Marsha Wolfson
Mar 3, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Simon DesmeulesBernard Canaud
Jun 16, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shahid M ChandnaKen Farrington
Mar 25, 2006·Blood Purification·Frank M van der SandeKarel M L Leunissen
Jun 16, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sangeeta D SuleSusan L Furth
Sep 25, 2010·Journal of the American Society of Nephrology : JASN·Gabriel ContrerasUNKNOWN African-American Study of Kidney Disease, and Hypertension Study Group
Dec 19, 2013·Current Opinion in Lipidology·Vasil PeevGabriel Contreras
Sep 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G A Kaysen
Mar 29, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M Haubitz, R Brunkhorst
Mar 31, 2000·Seminars in Dialysis·J Y Yeun
Dec 29, 2000·Seminars in Dialysis·T I Steinman
Mar 30, 2005·Nephron. Clinical Practice·Chung-Ying HungChwei-Shiun Yang
Sep 29, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sangeeta D SuleSusan L Furth
Jan 22, 2005·Seminars in Dialysis·Burl R Don, George Kaysen
Aug 9, 2006·Seminars in Dialysis·Devasmita Choudhury
Jan 10, 2008·Blood Purification·Francesco LocatelliUNKNOWN Membrane Permeability Outcome (MPO) Study Group
Jul 7, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Koichi Kaikita, Kenichi Tsujita
Jan 1, 2001·Hemodialysis International·M José Fernández-ReyesRafael Selgas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Mineral and Electrolyte Metabolism
George A KaysenT A Depner
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
J Y Yeun, George A Kaysen
Nefrología : publicación oficial de la Sociedad Española Nefrologia
María José Fernández-ReyesA Vázquez
Medicinski pregled
Biserka Tirmenstajn-JankovićMilenko Zivanović
© 2021 Meta ULC. All rights reserved