PMID: 9542700Jun 6, 1998Paper

Determinants of cancer screening frequency: the example of screening for cervical cancer

The Journal of the American Board of Family Practice
P S Frame, J S Frame

Abstract

Cancer screening frequency should be based on the rate of progression of the disease and the sensitivity of the screening test. A common misconception is that a person's risk of getting the disease determines how often they should be screened. We describe algebraically the theoretical interaction of disease progression rate and screening test sensitivity determining the portion of invasive cancers prevented by screening. After discussing the assumptions and limitations of the model, we apply this model to the example of screening for cervical cancer. Actual data from large screening programs assembled by the International Agency for Research on Cancer (IARC) are used to test the assumptions of the model. A simple formula can express the relation between disease progression rate, sensitivity of the screening test, screening frequency, and screening error. Disease prevalence does not figure in this equation. The IARC data suggest that, at least for cervical cancer, as screening frequency increases, incremental sensitivity of the test decreases or remaining undetected cases progress more rapidly so that anticipated benefits from more frequent screening are not realized. Rate of disease progression and sensitivity of the screening ...Continue Reading

Citations

Apr 7, 2004·Preventive Medicine·Maria Eugenia Fernández-Esquer, Marylou Cardenas-Turanzas
Oct 18, 2006·Journal of Lower Genital Tract Disease·P BralyJ T Cox
Oct 20, 2006·Journal of Lower Genital Tract Disease·D Kurtycz
Oct 20, 2006·Journal of Lower Genital Tract Disease·Debbie SaslowCarmel Cohen
Mar 11, 2004·Journal of General Internal Medicine·Brenda E Sirovich, H Gilbert Welch
Mar 5, 2008·The International Journal of Health Planning and Management·Alison Hann, Stephen Peckham
Oct 29, 2015·Critical Reviews in Food Science and Nutrition·Laura CornaraBruno Burlando
May 24, 2001·The New England Journal of Medicine·G F SawayaA M Garber
Sep 19, 2003·Journal of Women's Health·Mack T Ruffin
Apr 11, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M H Stoler
Jan 30, 2016·PloS One·Steffie K NaberMarjolein van Ballegooijen

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