Determinants of decline of renal function in treated hypertensive patients: the Campania Salute Network

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Costantino MancusiMaria Angela Losi

Abstract

Hypertension is a leading cause of chronic kidney disease (CKD) and a decrease in glomerular filtration rate (GFR) is associated with a higher prevalence of hypertension and an increased proportion of suboptimal blood pressure (BP) control. To investigate characteristics associated with GFR decline, we selected 4539 hypertensive patients from the Campania Salute Network (mean age 53 ± 11 years) with at least 3 years of follow-up (FU) and no more than Stage III CKD. GFR was calculated at baseline and at the last available visit using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. GFR decline was defined as a ≥30% decrease from initial GFR for patients in Stage III CKD or by a composite ≥30% decrease from baseline and a final value of <60 for those < with Stage III or higher CKD. At a mean FU of 7.5 years, 432 patients (10%) presented with GFR decline. Those patients were older, more likely to be diabetic, with lower GFR and ejection fraction, higher systolic and lower diastolic BP and higher left ventricular (LV) mass and relative wall thickness at baseline; during FU, patients with GFR decline exhibited higher systolic BP, took more drugs and developed more atrial fibrillation (all P < 0.02). The prob...Continue Reading

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Citations

Jun 12, 2018·Expert Review of Precision Medicine and Drug Development·Michael T EadonArlene B Chapman
Jun 13, 2020·European Journal of Preventive Cardiology·Grazia CancielloMaria Angela Losi
Jun 15, 2018·Journal of Human Hypertension·Fabio AngeliGianpaolo Reboldi
Oct 19, 2019·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Costantino MancusiUNKNOWN Proposal of Young Investigator Group of the Italian Hypertension Society (Società Italiana dell’Ipertensione Arteriosa)
Feb 22, 2021·European Journal of Preventive Cardiology·Grazia CancielloMaria Angela Losi
Apr 10, 2018·International Journal of Cardiology·Costantino MancusiMaria-Angela Losi

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