Determinants of DHA levels in early infancy: differential effects of breast milk and direct fish oil supplementation

Prostaglandins, Leukotrienes, and Essential Fatty Acids
S J MeldrumS L Prescott

Abstract

Although omega (n)-3 long-chain polyunsaturated fatty acids (LCPUFA), particularly docosahexaenoic acid (DHA), intakes are important during infancy, the optimal method of increasing infant status remains unclear. We hypothesized that high-dose infant fish oil supplementation would have greater relative effects upon n-3 LCPUFA status at six months of age than breast milk fatty acids. Infants (n=420) were supplemented daily from birth to six months with fish oil or placebo. In a subset of infants, LCPUFA levels were measured in cord blood, breast milk and in infant blood at 6 months. DHA levels increased in the fish oil group relative to placebo (p<05). Breast milk DHA was the strongest predictor of infant erythrocyte DHA levels (p=<001). This remained significant after adjustment for cord blood DHA, supplementation group and adherence. In this cohort, breast milk DHA was a greater determinant of infant erythrocyte n-3 LCPUFA status, than direct supplementation with fish oil.

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Sep 21, 2010·The Journal of Pediatrics·Christina J ValentineLynette K Rogers

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Citations

Nov 6, 2012·TheScientificWorldJournal·Juliana Rombaldi BernardiPatrícia Pelufo Silveira
Jun 9, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Sandra GellertAndreas Hahn
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Tim SchindlerDavid A Osborn
Oct 9, 2018·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Stephanie SmithHee-Yong Kim

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