Determinants of early carotid atherosclerosis progression in young patients with type 1 diabetes mellitus

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
Dietmar FrostW Beischer

Abstract

The results of cross-sectional studies addressing early preintrusive atherosclerosis in type 1 diabetic patients are conflicting. In an observational longitudinal study we determined the course of carotid artery intima-media thickness (IMT) over a period of 2.5 years in mean. A total of 102 patients with type 1 diabetes mellitus (age < or = 40 years, diabetes duration > or = 2 years at baseline examination) who were participants of the baseline examination was studied again in a follow-up. HbA1c, albumin excretion rate (AER), lipids, systolic and diastolic blood pressure, retinopathy, and current smoking status were assessed at baseline and follow-up. The IMT of the common carotid artery was measured by high-resolution ultrasound, the maximum IMT was evaluated. The annual progression rate (APR) was calculated from the difference between baseline and follow-up IMT reading and the time between both examinations. The follow-up IMT was significantly higher, compared to the baseline measurement: 0.65 +/- 0.18 vs. 0.57 +/- 0.14 mm (p < 0.001), the mean APR was 0.033 mm/year. The APR was correlated with age (r = 0.337, p < 0.01), diabetes duration (r = 0.252, p < 0.05), hypertension (r = 0.225, p < 0.05), and systolic blood pressure (...Continue Reading

Citations

Mar 6, 2004·Diabetes Technology & Therapeutics·Amish Parikh, Denis Daneman
May 1, 2004·Diabetes Technology & Therapeutics·Elizabeth BergerDenis Daneman
Mar 31, 2011·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Latika SibalPhilip D Home
Jul 8, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Aleksandra AraszkiewiczBogna Wierusz-Wysocka
Oct 27, 2006·Diabetes Care·Trevor J OrchardRichard W Nesto
Nov 25, 2004·Diabetes Care·Michael J HallerJanet H Silverstein
Oct 25, 2002·Diabetes/metabolism Research and Reviews

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