Determinants of eosinophil cationic protein in nasal lavages in children

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
C WojnarowskiT Frischer

Abstract

Nasal lavages are increasingly used to assess airways inflammation in children. However, there are no studies assessing how measurement error as well as biological influences contribute to the concentration of nasal inflammatory parameters in a population based survey. To investigate determinants of concentration of eosinophil cationic protein (ECP) in nasal lavages we studied 147 schoolchildren (mean age 8.1 years, SD 0.6 years) by repeated nasal lavages/year over a 2 year period. Standardized questionnaires were completed by the parents each year. A skin-prick test with seven aeroallergens (birch, cat, dog, hazel, weeds, Dermatophagoides pteronyssinus and D. farinae) was performed. One hundred and one children could perform valid lavages at least five times a year. As a measure of reproducibility the intraclass coefficient of reliability was calculated. The intraclass coefficient of reliability was 0.27 over all observations suggesting that about a quarter of total variance is due to between-subject variance. Taking means over each year increased reliability to 0.60. Linear regression analyses with ECP being the dependent variable demonstrated significant higher values for boys (beta=12.26; P < 0.01), children sensitized to s...Continue Reading

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Citations

Mar 5, 2005·The Journal of Allergy and Clinical Immunology·Peter H HowarthPhilip E Silkoff
Feb 28, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Terry L NoahFrederick W Henderson
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Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·T Frischer, E Baraldi
Jun 26, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C WojnarowskiT Frischer
May 21, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D Y KollerB Roithner
Aug 13, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·O D Wolthers

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