Determinants of exhaled nitric oxide levels (FeNO) in childhood atopic asthma: evidence for neonatal respiratory distress as a factor associated with low FeNO levels

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Fabio L M RicciardoloGiovanni A Rossi

Abstract

In allergic asthmatic children exhaled nitric oxide (FeNO) levels are related to eosinophilic inflammation by correlation analysis. Whether FeNO can be modified by factors potentially influencing the natural history of asthma in early life is not known. To evaluate the frequency of anamnestic factors influencing the natural history of asthma and to identify potential determinants for elevated or low FeNO levels by multivariate analysis. One hundred seventy-one children with mild-moderate asthma were stratified according to their FeNO levels into three groups: low (<20 ppb), mid (20-40 ppb), and high (>40 ppb). The frequency of nine anamnestic factors together with indices of allergic sensitization (total and allergen-specific immunoglobulin E [IgE], blood eosinophil counts) and of airflow limitation (forced expiratory volume in one second [FEV(1)]% predicted) were evaluated. Results. Among factors related to the patient history, neonatal respiratory distress was reported only in children with low FeNO levels, whereas this factor was never reported in children with mid-to-high FeNO levels (p = .008). As compared with low FeNO group, mid and high FeNO groups showed higher eosinophil counts and a tendency to have lower FEV(1) valu...Continue Reading

References

Jul 1, 1996·American Journal of Respiratory and Critical Care Medicine·D H YatesP J Barnes
Jan 5, 1999·American Journal of Respiratory and Critical Care Medicine·S LimP J Barnes
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A TrifilieffC Bertrand
Jul 28, 2001·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·N M WilsonA Bush
Nov 3, 2001·The Journal of Allergy and Clinical Immunology·S KonnoM Nishimura
Nov 16, 2001·Biochemical Pharmacology·S M ThomazziE Antunes
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Philip W ShaulDonald C McCurnin
Feb 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J G C van AmsterdamB Brunekreef
Mar 26, 2003·Experimental Lung Research·Jeffrey C HoytPeter J Barnes
Oct 2, 2003·Pediatric Pulmonology·Avraham AvitalChaim Springer
Nov 12, 2003·The Journal of Allergy and Clinical Immunology·Robert C StrunkUNKNOWN Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute
Nov 15, 2003·Journal of Clinical Epidemiology·Afina S GlasPatrick M M Bossuyt
Nov 18, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L F JouavilleD Caillaud
Dec 3, 2003·American Journal of Respiratory and Critical Care Medicine·Andrew D SmithD Robin Taylor
Dec 17, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Oliviero SaccoGiovanni A Rossi
Jul 23, 2004·Physiological Reviews·Fabio L M RicciardoloGert Folkerts
Sep 10, 2004·The Journal of Allergy and Clinical Immunology·Junpei SaitoMitsuru Munakata
Oct 13, 2004·American Journal of Respiratory and Critical Care Medicine·Eugenio BaraldiMarco Filippone
Jan 12, 2005·Current Opinion in Allergy and Clinical Immunology·David Proud
Apr 14, 2005·Cytokine·A B Paoliello-PaschoalatoF Q Cunha
Jun 9, 2005·The Journal of Allergy and Clinical Immunology·Frederik BuchvaldHans Bisgaard
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Feb 9, 2006·European Journal of Pharmacology·Fabio L M RicciardoloGert Folkerts
Dec 7, 2006·Clinics in Perinatology·Tonse N K Raju
Oct 22, 2008·American Journal of Respiratory and Critical Care Medicine·Johan C de JongsteEugenio Baraldi
Mar 1, 1993·The European Respiratory Journal·P H QuanjerJ C Yernault

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Citations

Nov 20, 2012·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Giorgio CiprandiMichele Capasso
Jan 14, 2016·Expert Review of Clinical Immunology·Devika R Rao, Wanda Phipatanakul
Jun 28, 2011·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·S Pérez TarazonaJ Talens Gandía
Jul 23, 2016·Clinical Reviews in Allergy & Immunology·Songqi TangYubao Cui
Mar 2, 2011·Current Opinion in Otolaryngology & Head and Neck Surgery·Michael N Pakdaman, Amber Luong
Jul 29, 2021·Pediatric Pulmonology·Fanny E M GothInger M Jørgensen

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