Determinants of Gammaherpesvirus Shedding in Saliva Among Ugandan Children and Their Mothers.

The Journal of Infectious Diseases
Robert NewtonDenise Whitby

Abstract

Epstein-Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) are transmitted via saliva, but factors associated with salivary shedding are unknown. We measured the DNA load of both viruses in saliva specimens collected from approximately 500 Ugandan mothers and their 6-year-old children, testing all participants for EBV and KSHV-seropositive individuals for KSHV. EBV and KSHV were shed by 72% and 22% of mothers, respectively, and by 85% and 40% of children, respectively; boys were more likely than girls to shed KSHV (48% vs 30%) but were equally likely to shed EBV. Children shed more KSHV and EBV than mothers, but salivary loads of EBV and KSHV were similar. KSHV shedding increased with increasing anti-KSHV (K8.1) antibodies in mothers and with decreasing antimalarial antibodies both in mothers and children. Among mothers, 40% of KSHV shedders also shed EBV, compared with 75% of KSHV nonshedders; among children, EBV was shed by 65% and 83%, respectively. In summary, in this population, individuals were more likely to shed EBV than KSHV in saliva. We identified several factors, including child's sex, that influence KSHV shedding, and we detected an inverse relationship between EBV and KSHV shedding, suggesting a dir...Continue Reading

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Citations

Jul 3, 2019·International Journal of Cancer. Journal International Du Cancer·Nazzarena LaboDenise Whitby
Sep 27, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Angela NalwogaRobert Newton
Nov 23, 2019·Viruses·Stephen J Dollery
Jan 12, 2020·Cancer Epidemiology·W T JohnstonEve Roman
May 20, 2021·Analytical Methods : Advancing Methods and Applications·Mengmeng LiuChao Shi

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