PMID: 7007799Jan 1, 1981Paper

Determinants of gastric inhibitory polypeptide and insulin secretion

Metabolism: Clinical and Experimental
R H WilliamsJ B Biesbroeck

Abstract

The plasma concentrations of gastric inhibitory polypeptide (IR-GIP), insulin, and glucose were measured in 5 dogs after administration of various constituents of food. IR-GIP responses produced by galactose and fructose were minimal compared to those of glucose. Corn starch caused a significant early increase in insulin and glucose concentrations, although the rise in IR-GIP was delayed. The responses after starch were delayed, possibly due to the necessity for hydrolytic cleavage. Neither individual fatty acids (palmitic, oleic, and linoleic), monoolein, nor glycerol produced increases in IR-GIP comparable to those observed with lesser amounts (on a molar basis) of corn oil alone. None of four amino acids tested orally (arginine, leucine, alanine, and phenylalanine) caused increases in IR-GIP concentrations, but they increased insulin concentrations. Although glucose-induced IR-GIP responses were not inhibited by the amino acids (1 g/kg) tested, increasing concentrations (up to 1 g/kg) of either alanine or arginine caused progressive inhibition of corn-oil-stimulated IR-GIP responses, in spite of the expected amino-acid-induced rises in insulin concentrations. These results confirm the specificity of the IR-GIP secretory resp...Continue Reading

References

Jan 1, 1977·Annual Review of Physiology·W ValeM Brown
Jan 1, 1978·Annual Review of Biochemistry·A V SchallyC A Meyers
Aug 1, 1975·The Journal of Clinical Endocrinology and Metabolism·J M FalkoE L Mazzaferri
Sep 1, 1972·The Journal of Clinical Endocrinology and Metabolism·J W EnsinckR H Williams
Aug 1, 1974·The Journal of Clinical Endocrinology and Metabolism·S CatalandE L Mazzaferri
Sep 1, 1972·The Journal of Clinical Investigation·D M RochaR H Unger
Feb 1, 1968·The Journal of Physiology·E EliasJ H Tripp
Oct 1, 1963·The Biochemical Journal·F C GREENWOODJ S GLOVER

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Citations

Jun 1, 1988·Journal of the American College of Nutrition·C K LardinoisE L Mazzaferri
Dec 16, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Dennis B HenriksenClaus Christiansen

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