Determinants of glycemic control in youth with type 2 diabetes at randomization in the TODAY study.

Pediatric Diabetes
Fida BachaTODAY Study Group

Abstract

To investigate insulin sensitivity and secretion indices and determinants of glycemic control in youth with recent-onset type 2 diabetes (T2DM) at randomization in the TODAY study, the largest study of youth with T2DM to date. We examined estimates of insulin sensitivity [1/fasting insulin (1/I(F)), fasting glucose/insulin (G(F) /I(F)), 1/fasting C-peptide (1/C(F)), G(F) /C(F)], β-cell function [insulinogenic index (ΔI30/ΔG30), and ΔC30/ΔG30], and disposition index (DI) in the TODAY cohort of 704 youth (14.0 ± 2.0 yr; diabetes duration 7.8 ± 5.8 months; 64.9% female; 41.1% Hispanic, 31.5% Black, 19.6% White, 6.1% American Indian, and 1.7% Asian) according to hemoglobin A1c (HbA1c) quartiles at study randomization. The randomization visit followed a run-in period (median 71 d) during which glycemic control (HbA1c ≤ 8% for at least 2 months) was achieved with metformin alone. These measures were also examined in relation to screening HbA1c levels before run-in. Insulin secretion indices declined with increasing HbA1c quartiles, at randomization (ΔC30/ΔG30: 0.11 ± 0.09, 0.10 ± 0.19, 0.07 ± 0.06, and 0.03 ± 0.03 ng/mL per mg/dL, p < 0.0001; DI: 0.03 ± 0.03, 0.03 ± 0.05, 0.02 ± 0.02, and 0.01 ± 0.01 mg/dL(-1) , p < 0.0001) and at sc...Continue Reading

References

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Citations

Oct 9, 2015·Annals of the New York Academy of Sciences·Tamara S Hannon, Silva A Arslanian
Aug 24, 2012·Pediatric Diabetes·Fida BachaSilva A Arslanian
Feb 19, 2015·Pediatric Diabetes·Megan M KelseyUNKNOWN Treatment Options for Type 2 Diabetes in Adolescents and Youth Study Group
May 6, 2015·Pediatric Diabetes·Brigid GreggUNKNOWN Pediatric Diabetes Consortium
Mar 18, 2015·Current Diabetes Reports·Philip ZeitlerMitchell Geffner
Apr 27, 2018·Diabetes/metabolism Research and Reviews·Jacob V StidsenHenning Beck-Nielsen
Dec 19, 2018·American Journal of Physiology. Endocrinology and Metabolism·Melanie Cree-GreenKristen J Nadeau
Jul 2, 2019·PloS One·Mary Margaret BarrAmbika P Ashraf
Jun 18, 2018·Current Diabetes Reports·Melinda E ChenTamara S Hannon
Apr 3, 2020·Seminars in Pediatric Surgery·Amy S ShahMegan M Kelsey
Nov 22, 2017·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Petter BjornstadUNKNOWN TODAY Study Group

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