PMID: 16532211Mar 15, 2006Paper

Determinants of HIV-1 mother-to-child transmission in Southern Brazil

Anais Da Academia Brasileira De Ciências
Ana M B MartínezHIV/AIDS Unit

Abstract

Different human immunodeficiency virus type 1 (HIV-1) subtypes may have distinct biological, immunological and pathogenic properties. Efficiency of mother-to-child transmission (MTCT) may be among those properties, but few and controversial results have been described so far. In this study, 102 children born from HIV-1-infected mothers between 1998 and 2004 in the city of Rio Grande, Brazil were analyzed for potential risk factors associated with MTCT. That geographic region is characterized by a high proportion of subtype C-infected subjects, and it allowed comparison between subtypes B and C and their influence on MTCT. The analysis also included clinical, obstetric and immunological parameters. Multivariate regression analyses were conducted to evaluate the influence of the parameters on MTCT, and prevalence ratios (PR) and 95% confidence intervals (CI95) were also calculated. A surprisingly high prevalence of subtype C of over 70% was found. Only the HIV viral load and the use of ACTG 076 protocol were predictive of MTCT. HIV subtype and CD4 T-cell counts were not associated with increased risk of transmission. Although a clear expansion of subtype C is evident in southern Brazil, it does not seem to correlate with increase...Continue Reading

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Citations

Jul 2, 2015·Jornal de pediatria·Matheus Costa da RosaVanusa Pousada da Hora
Feb 14, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jussara SilveiraDirceu B Greco
Feb 23, 2011·Revista Da Sociedade Brasileira De Medicina Tropical·Vera Lúcia Maria Alves GonçalvesLuiz Euribel Prestes-Carneiro
May 26, 2010·International Journal of STD & AIDS·M TornatoreA M B Martinez
Nov 20, 2010·AIDS Research and Human Retroviruses·Joana Paixao Monteiro-CunhaLuiz Carlos Junior Alcantara
Apr 13, 2017·AIDS Research and Human Retroviruses·Manickam AshokkumarLuke Elizabeth Hanna
Mar 26, 2010·AIDS Research and Human Retroviruses·Rosangela RodriguesLuis Fernando de Macedo Brigido
Sep 19, 2019·Clinics·Mariana Fernandes GuimarãesClaudete Aparecida Araújo Cardoso

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