Determinants of improved survival after oesophagectomy for cancer

The British Journal of Surgery
A K TalsmaB P L Wijnhoven

Abstract

Survival after oesophagectomy for cancer seems to be improving. This study aimed to identify the most important contributors to this change. Patients who underwent oesophagectomy from 1999 to 2010 were extracted from the Netherlands Cancer Registry. Four time periods were compared: 1999-2001 (period 1), 2002-2004 (period 2), 2005-2007 (period 3) and 2008-2010 (period 4). Hospital type, tumour location, tumour type, tumour differentiation, neoadjuvant therapy, operation type, (y)pT category, involvement of surgical resection margins, number of removed lymph nodes and number of involved lymph nodes were investigated in relation to trends in survival using multivariable analysis. A total of 4382 patients were identified. Two-year overall survival rates improved from 49·3 per cent in period 1 to 58·4, 56·2 and 61·0 per cent in periods 2, 3 and 4 respectively (P < 0·001). Multivariable survival analysis revealed that the improvement in survival between periods 3 and 4 was related to the introduction of neoadjuvant therapy. The improvement in survival between periods 1 and 2 could not be explained completely by the factors studied. The number of examined lymph nodes increased, especially between periods 2 and 3, but this increase was...Continue Reading

Associated Clinical Trials

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Citations

Jul 19, 2017·The British Journal of Surgery·D W KjaerL S Jensen
Nov 15, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Dhruvin H HirparaGail E Darling
Mar 5, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yutian LaiYang Hu
Mar 17, 2019·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Maria J ValkemaRoelf Valkema

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