Abstract
Intracranial hemorrhage is the most dreaded complication of neurothrombectomy therapy for acute ischemic stroke. The determinants of intracranial hemorrhage and its impact on clinical course remain incompletely delineated. The purpose of this study is to further investigate the clinical and procedural factors leading to intracranial hemorrhage and to define the clinical impact of different hemorrhagic subtypes. We analyzed data prospectively collected in the Solitaire FR With Intention for Thrombectomy randomized clinical trial. A multivariable logistic regression model was used to identify independent clinical, imaging, and procedural predictors of any intracranial hemorrhage and of 7 intracranial hemorrhage subtypes. Univariate analysis was used to determine the impact of each of the intracranial hemorrhage subtypes on clinical outcome. Among the 144 enrolled patients, any radiologic intracranial hemorrhage (21.3% versus 38.2%, P = .035), symptomatic intracranial hemorrhage (1.1% versus 10.9%, P = .012), and subarachnoid hemorrhage (2.2% versus 12.7%, P = .027) occurred less frequently in the Solitaire FR than in the Merci retriever arms. The most common independent determinant of hemorrhage occurrence was rescue therapy with...Continue Reading
References
Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Dec 11, 1999·JAMA : the Journal of the American Medical Association·A FurlanF Rivera
Feb 7, 2001·Stroke; a Journal of Cerebral Circulation·V LarrueE Bluhmki
Oct 30, 2004·Stroke; a Journal of Cerebral Circulation·Y Pierre GobinJeffrey L Saver
Jun 18, 2005·Stroke; a Journal of Cerebral Circulation·Wade S SmithUNKNOWN MERCI Trial Investigators
Jan 30, 2007·Lancet·Nils WahlgrenUNKNOWN SITS-MOST investigators
Feb 20, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·C BrekenfeldG Schroth
Jul 21, 2007·Stroke; a Journal of Cerebral Circulation·Jeffrey L Saver
Aug 9, 2007·Annals of Neurology·Oh Young BangDavid S Liebeskind
Mar 1, 2008·Stroke; a Journal of Cerebral Circulation·Wade S SmithIsaac E Silverman
Sep 5, 2008·AJNR. American Journal of Neuroradiology·G A ChristoforidisA P Slivka
Sep 6, 2008·Stroke; a Journal of Cerebral Circulation·Pooja KhatriUNKNOWN IMS I and II Investigators
Jul 11, 2009·Stroke; a Journal of Cerebral Circulation·UNKNOWN Penumbra Pivotal Stroke Trial Investigators
Aug 8, 2009·Stroke; a Journal of Cerebral Circulation·Yince LohGary R Duckwiler
Nov 6, 2010·Stroke; a Journal of Cerebral Circulation·Zhong-Song ShiUNKNOWN UCLA Endovascular Stroke Therapy Investigators
Aug 31, 2012·Lancet·Jeffrey L SaverUNKNOWN SWIFT Trialists
Nov 8, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·J L SaverUNKNOWN SWIFT Trialists
Sep 14, 2013·AJNR. American Journal of Neuroradiology·P T AkinsUNKNOWN SWIFT Investigators
Sep 28, 2013·Stroke; a Journal of Cerebral Circulation·Alexander C FlintUNKNOWN VISTA Collaboration
Citations
Nov 14, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yuri SugiuraUNKNOWN Committee of Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism (RESCUE)-Japan Study Group
Sep 10, 2017·Stroke; a Journal of Cerebral Circulation·Kunakorn AtchaneeyasakulNatalia S Rost
Sep 9, 2018·Journal of Neurointerventional Surgery·Kubilay AydinSergin Akpek
Jun 16, 2019·Expert Review of Neurotherapeutics·Zilong HaoMing Liu
Sep 15, 2019·Neurology·Grégoire BoulouisHilde Henon
Dec 10, 2019·JAMA Neurology·Johannes KaesmacherUrs Fischer
Dec 10, 2019·JAMA Neurology·Victor Lopez-Rivera, Sunil A Sheth
Jun 2, 2020·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Masaya EnomotoTeruyuki Hirano
Jun 27, 2019·Journal of Neurointerventional Surgery·Radoslav RaychevDavid S Liebeskind
Oct 20, 2020·Stroke; a Journal of Cerebral Circulation·Johanna M OspelMayank Goyal
Sep 17, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P Constant Dit BeaufilsUNKNOWN Endovascular Treatment in Ischemic Stroke (ETIS) Research Investigators
Jan 31, 2021·Journal of Neurointerventional Surgery·Johannes KaesmacherUrs Fischer
Mar 18, 2021·Curēus·Destiny HooperRajan Gadhia
Jul 31, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Ling LiYunfeng Bao
Dec 8, 2021·Stroke; a Journal of Cerebral Circulation·Bing TianUNKNOWN DIRECT-MT Investigators