Determinants of Intracranial Hemorrhage Occurrence and Outcome after Neurothrombectomy Therapy: Insights from the Solitaire FR With Intention For Thrombectomy Randomized Trial.

AJNR. American Journal of Neuroradiology
R RaychevSWIFT Trial Investigators

Abstract

Intracranial hemorrhage is the most dreaded complication of neurothrombectomy therapy for acute ischemic stroke. The determinants of intracranial hemorrhage and its impact on clinical course remain incompletely delineated. The purpose of this study is to further investigate the clinical and procedural factors leading to intracranial hemorrhage and to define the clinical impact of different hemorrhagic subtypes. We analyzed data prospectively collected in the Solitaire FR With Intention for Thrombectomy randomized clinical trial. A multivariable logistic regression model was used to identify independent clinical, imaging, and procedural predictors of any intracranial hemorrhage and of 7 intracranial hemorrhage subtypes. Univariate analysis was used to determine the impact of each of the intracranial hemorrhage subtypes on clinical outcome. Among the 144 enrolled patients, any radiologic intracranial hemorrhage (21.3% versus 38.2%, P = .035), symptomatic intracranial hemorrhage (1.1% versus 10.9%, P = .012), and subarachnoid hemorrhage (2.2% versus 12.7%, P = .027) occurred less frequently in the Solitaire FR than in the Merci retriever arms. The most common independent determinant of hemorrhage occurrence was rescue therapy with...Continue Reading

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Citations

Nov 14, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yuri SugiuraUNKNOWN Committee of Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism (RESCUE)-Japan Study Group
Sep 10, 2017·Stroke; a Journal of Cerebral Circulation·Kunakorn AtchaneeyasakulNatalia S Rost
Sep 9, 2018·Journal of Neurointerventional Surgery·Kubilay AydinSergin Akpek
Jun 2, 2020·Interventional Neuroradiology : Journal of Peritherapeutic Neuroradiology, Surgical Procedures and Related Neurosciences·Masaya EnomotoTeruyuki Hirano
Oct 20, 2020·Stroke; a Journal of Cerebral Circulation·Johanna M OspelMayank Goyal
Sep 17, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·P Constant Dit BeaufilsUNKNOWN Endovascular Treatment in Ischemic Stroke (ETIS) Research Investigators
Jul 31, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Ling LiYunfeng Bao
Dec 8, 2021·Stroke; a Journal of Cerebral Circulation·Bing TianUNKNOWN DIRECT-MT Investigators

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