Determinants of lipoprotein(a) levels in a middle-aged working population

European Heart Journal
L BraeckmanG De Backer

Abstract

The association between blood lipids, apolipoproteins, fibrinogen, life-style-related factors and lipoprotein(a) was assessed in a cohort of middle-aged men. Male employees, working in local industry, were invited to participate in a health survey at their worksite. After exclusion of nine persons with prevalent diabetes and 14 subjects with a history of myocardial infarction or angina, data were available on 720 healthy Caucasian men. Lipoprotein(a) concentration was measured using an enzyme-linked immunosorbent assay (ELISA), and distribution was found to be highly skewed with a median level of 9 mg.dl-1 (mean level 23.1 mg.dl-1). The percentage of subjects with lipoprotein(a) levels higher than 30 mg.dl-1 was 23.6%. Univariate analysis showed a significant association between lipoprotein(a) and age, total cholesterol, apolipoprotein B and fibrinogen. However, no relationship was found with body mass index, waist to hip ratio, smoking, blood pressure, alcohol consumption, diet, HDL cholesterol, apolipoprotein AI and apolipoprotein E concentration or apolipoprotein E polymorphism. In multivariate analysis, In-transformed lipoprotein(a) correlated positively with apolipoprotein B (P < 0.0001) and fibrinogen (P = 0.004). Proport...Continue Reading

Citations

Jul 23, 2009·JAMA : the Journal of the American Medical Association·UNKNOWN Emerging Risk Factors CollaborationJohn Danesh
Jun 30, 2004·Scandinavian Journal of Clinical and Laboratory Investigation·K AasveeJ Sundvall
Jul 14, 2010·Progress in Cardiovascular Diseases·Kolli Srinath Reddy, Ambika Satija
Sep 27, 2012·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Émilie MarrerMichel Velten
Dec 14, 2006·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Emmanuel S GanotakisDimitri P Mikhailidis
Apr 16, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Emoke PósánMiklós Udvardy

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