Determinants of long-term outcome of patients with reflux-related ear, nose, and throat symptoms

Digestive Diseases and Sciences
Johan PoelmansJan Tack

Abstract

Gastroesophageal reflux disease (GERD) is present in up to 75% of patients with chronic refractory ear, nose, and throat (ENT) symptoms, and proton pump inhibitor (PPI) therapy induces symptom relief in the majority of these patients. It has been suggested that endoscopic findings and quantification of esophageal acid exposure may help to predict the long-term outcome of medical therapy, but prospective studies that confirm this hypothesis are lacking. The aim of the present study was to investigate the relationship of endoscopic findings and quantification of reflux with long-term outcome in patients with reflux-related ENT symptoms. One hundred six consecutive patients with chronic refractory unexplained ENT symptoms underwent upper GI endoscopy, 24-hr dual-channel esophageal pH and Bilitec (n = 35) monitoring, and esophageal manometry. Subsequently, all were treated with omeprazole, 20 mg b.i.d., and patients were followed at 2-week intervals until symptom relief. Four weeks later, omeprazole therapy was gradually decreased and the lowest effective omeprazole maintenance dose, if any, was determined. Eighty-one patients (49 men; mean age, 50) experienced a clear or excellent therapeutic response after, on average, 4 weeks of...Continue Reading

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References

Dec 1, 1991·The Laryngoscope·J A Koufman
Aug 1, 1989·Journal of Clinical Pathology·T L Miko
Nov 1, 1988·The Laryngoscope·P H Ward, D G Hanson
Jul 1, 1987·The Annals of Otology, Rhinology, and Laryngology·S J OssakowT T Nostrant
Sep 1, 1985·The Annals of Otology, Rhinology, and Laryngology·F B LittleR B Marshall
Nov 1, 1968·The Laryngoscope·J Cherry, S I Margulies
May 1, 1983·The Annals of Otology, Rhinology, and Laryngology·L OhmanG Ericsson
May 1, 1980·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·P H WardG Berci
Jul 1, 1995·The Annals of Otology, Rhinology, and Laryngology·D G HansonP J Kahrilas
Apr 1, 1994·The American Journal of Medicine·P L KamelP J Kahrilas
Apr 1, 1996·The American Journal of Medicine·S M HardingL A Bradley
Mar 1, 1996·The Gastroenterologist·K R DeVault
Dec 1, 1996·The Laryngoscope·C J Loughlin, J A Koufman
Dec 1, 1996·Journal of Gastroenterology·D JaspersenW Draf
Dec 29, 1998·Annals of Internal Medicine·J K DiBaiseE M Quigley
Sep 3, 1999·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M R BothwellB Wilder
Oct 16, 1999·The American Journal of Gastroenterology·E J Ormseth, R K Wong
Jul 11, 2000·Archives of Otolaryngology--head & Neck Surgery·C D PhippsW J Cochran
Apr 24, 2001·The American Journal of Gastroenterology·H B El-SeragD M McCarthy
Jul 13, 2001·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·J PoelmansL Feenstra
Dec 26, 2001·The American Journal of Medicine·M F Vaezi, J E Richter
Feb 21, 2002·Lancet·Andrea TaskerJeffery P Pearson
May 11, 2002·The American Journal of Gastroenterology·John K DiBaiseEamonn M M Quigley
Oct 23, 2002·The Annals of Otology, Rhinology, and Laryngology·Johan PoelmansLouw Feenstra
Jul 23, 2003·Digestive Diseases and Sciences·Jan TackJozef Janssens
Dec 2, 2004·The American Journal of Gastroenterology·Mike CoolJan Tack
May 24, 2005·Digestive Diseases and Sciences·J PoelmansJ Tack

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Citations

Mar 28, 2008·Surgical Endoscopy·Mohd IqbalR T Spychal
Apr 6, 2011·Current Gastroenterology Reports·Jaclyn A SmithLesley A Houghton
Dec 25, 2008·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Mohd IqbalBrian T Cooper
Nov 6, 2010·World Journal of Surgery·Dharmendran RatnasingamDavid I Watson
Mar 24, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jérôme R LechienSven Saussez
Jun 28, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Mustafa SahinSerhat Bor
May 3, 2016·Journal of Voice : Official Journal of the Voice Foundation·Jérôme R LechienSven Saussez
Mar 23, 2011·Toxicologic Pathology·Siegrid DamschAlfred Tonelli
May 17, 2018·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·J R LechienS Saussez
Mar 17, 2010·Pain Practice : the Official Journal of World Institute of Pain·Nagaaki SuzukiMasakazu Nishibori
Nov 23, 2011·Journal of Clinical Gastroenterology·Shahin AyaziMajid Hashemi
May 28, 2019·Folia Phoniatrica Et Logopaedica : Official Organ of the International Association of Logopedics and Phoniatrics (IALP)·Jérôme R LechienSven Saussez

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