Apr 1, 1976

Determinants of lung bacterial clearance in normal mice

The Journal of Clinical Investigation
S J JayJ S Reisch

Abstract

The determinants of the lung clearance of Streptococcus pneumoniae, Klebsiella pneumoniae, Escherichia coli, and Staphylococcus aureus were studied in normal mice after exposure to an aerosol of viable bacteria and 99mTc-labeled dead bacteria. The fraction of bacteria in lungs that remained viable 4 h after exposure were: S. pneumoniae, 7.3%; K. pneumoniae, 121%; E. coli, 88.5%; S. aureus, 27.6%. The rate of physical removal of bacterial particles (Kmc) was determined from the change in lung 99mTc counts with time: Kmc ranged between 7 and 12%/h and and was similar in all species. The rate of mucociliary clearance and of intrapulmonary bacterial killing (Kk + Kmc) was calculated from the change in bacterial counts with time in animals that had received tetracycline to inhibit bacterial multiplication. Kk, the rate of intrapulmonary killing, was obtained by subtraction of Kmc from (Kk + Kmc). The calculated values for Kk were: S. pneumoniae, - 87%/h; K. pneumoniae, - 17%/h; E. coli, - 18%/h; S. aureus, - 22%/h. The rate of intrapulmonary bacterial multiplication (Kg) was estimated from the relationship of bacterial counts in tetracycline and nontetracycline-treated animals, assuming that tetracycline altered only Kg. Kg, express...Continue Reading

  • References7
  • Citations18

References

  • References7
  • Citations18

Citations

Mentioned in this Paper

Tetracycline Antibiotics
Antibiotic Resistance, Microbial
Tetracyclines
Mycoplasma pneumoniae
Alkalescens-Dispar Group
Lung
Thylacodes aureus
Klebsiella pneumoniae
Topicycline
Infection by Klebsiella Pneumoniae in Conditions Classified Elsewhere and of Unspecified Site

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