Determinants of LV dP/dtmax and QRS duration with different fusion strategies in cardiac resynchronisation therapy.

Open Heart
Hans Henrik OdlandErik Kongsgaard

Abstract

We designed this study to assess the acute effects of different fusion strategies and left ventricular (LV) pre-excitation/post-excitation on LV dP/dtmax and QRS duration (QRSd). We measured LV dP/dtmax and QRSd in 19 patients having cardiac resynchronisation therapy (CRT). Two groups of biventricular pacing were compared: pacing the left ventricle (LV) with FUSION with intrinsic right ventricle (RV) activation (FUSION), and pacing the LV and RV with NO FUSION with intrinsic RV activation. In the NO FUSION group, the RV was paced before the expected QRS onset. A quadripolar LV lead enabled distal, proximal and multipoint pacing (MPP). The LV was stimulated relative in time to either RV pace or QRS-onset in four pre-excitation/post-excitation classes (PCs). We analysed the interactions of two groups (FUSION/NO FUSION) with three different electrode configurations, each paced with four different degrees of LV pre-excitation (PC1-4) in a statistical model. LV dP/dtmax was higher with NO FUSION than with FUSION (769±46 mm Hg/s vs 746±46 mm Hg/s, p<0.01), while there was no difference in QRSd (NO FUSION 156±2 ms and FUSION 155±2 ms). LV dP/dtmax and QRSd increased with LV pre-excitation compared with pacing timed to QRS/RV pace-onse...Continue Reading

References

Mar 11, 2004·Pacing and Clinical Electrophysiology : PACE·Sander G MolhoekMartin J Schalij
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Michael R GoldJulio Spinelli
Dec 20, 2005·Journal of the American College of Cardiology·Berry M van GelderNico H J Pijls
Jun 15, 2010·JACC. Cardiovascular Imaging·Niraj VarmaYoram Rudy
Nov 3, 2011·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Matthew R GinksC Aldo Rinaldi
Nov 18, 2011·Journal of Cardiovascular Translational Research·Frits W Prinzen, Angelo Auricchio
Nov 23, 2011·Circulation·Bernard ThibaultUNKNOWN Evaluation of Resynchronization Therapy for Heart Failure (GREATER-EARTH) Investigators
Mar 1, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Bernard ThibaultTaraneh G Farazi
Jan 1, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Fraz UmarFrancisco Leyva
Mar 5, 2016·Journal of the American College of Cardiology·Jeanne E PooleUlrika Birgersdotter-Green
Apr 9, 2018·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Francesco ZanonFrits W Prinzen
Jul 6, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Charlotte StephansenJens Cosedis Nielsen
Jan 21, 2020·Computer Methods in Biomechanics and Biomedical Engineering·Mohammad AlbatatIlangko Balasingham
Feb 1, 2020·Journal of the American College of Cardiology·Floor C W M SaldenKevin Vernooy
Apr 17, 2020·Frontiers in Physiology·William W Muir, Robert L Hamlin

❮ Previous
Next ❯

Software Mentioned

LabChart Pro
MOre
FUSION
NO
SPSS

Related Concepts

Related Feeds

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.