Determinants of macroscopic anal cancer and precancerous lesions in 1206 HIV-infected screened patients

Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Laurent AbramowitzXavier Duval

Abstract

Anal screening is recommended in HIV-positive patients, especially men who have sex with men (MSM), due to an increased incidence of anal cancer. The optimal screening methods are not generally agreed. Screening for anal lesions by anorectal examination, including anoscopy, was offered to HIV-positive outpatients in a tertiary care university hospital regardless of gender or sexual orientation. Among the 1206 screened patients (701 MSM, 247 heterosexual men, 258 women), 311 (26%) had histologically proven lesions related to human papilloma virus (HPV) (34% MSM, 14% heterosexual men, 14% women); 123 (10%) had low-grade dysplasia and 70 (6%) high-grade dysplasia. Seven anal cancers were also diagnosed. Determinants of any lesion were age < 45 years [OR = 1.56 (95% CI, 1.16-2.11)], a CD4 count of < 200/mm(3) [OR = 2.54 (1.71-3.78)], receptive anal intercourse [OR =3.03 (2.06-4.47)], sub-Saharan African origin [OR = 0.53 (0.33-0.85)], and history of HPV-related lesion [OR = 1.84 (1.35-2.51)]. These determinants were similar for all different grades of dysplasia. In patient subgroup analysis, receptive anal intercourse, the CD4 cell count and a history of HPV lesions were determinants of HPV-positivity in all patients, whereas age w...Continue Reading

References

Feb 1, 1994·Genitourinary Medicine·A de RuiterA Mindel
Feb 18, 2009·Annals of Internal Medicine·Kenneth A KatzJeffrey D Klausner
Apr 28, 2009·Alimentary Pharmacology & Therapeutics·L AbramowitzI Sobhani
Jul 16, 2010·Diseases of the Colon and Rectum·Stephen E Goldstone, Erin Moshier
Sep 25, 2010·American Journal of Public Health·Mitchell H KatzJeffrey D Klausner
Jan 6, 2011·International Journal of Cancer. Journal International Du Cancer·Emilie LanoyUNKNOWN ONCOVIH study group
Aug 19, 2011·International Journal of Colorectal Disease·Maria das Graças F C CastorRoberto José Vieira de Mello
May 25, 2012·International Journal of Cancer. Journal International Du Cancer·Marc ArbynJoseph Monsonego
Feb 11, 2014·Diseases of the Colon and Rectum·Stephen E GoldstoneErin L Moshier
Jun 20, 2014·Journal of the International AIDS Society·Bruno HoenUNKNOWN 2013 French HIV expert group

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Citations

Jul 15, 2017·Inflammatory Bowel Diseases·Tracey MartinLisa B Malter
Jun 8, 2018·Diseases of the Colon and Rectum·David B StewartUNKNOWN Prepared on Behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons
Jul 17, 2021·American Journal of Surgery·Tonna McCutcheonRoberta L Muldoon
Aug 12, 2020·Annals of Coloproctology·Emilie LafferreFlorence Tubach

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