Determinants of Mammographic Density Change

JNCI Cancer Spectrum
Shadi AzamPer Hall

Abstract

Mammographic density (MD) is a strong risk factor for breast cancer. We examined how breast cancer risk factors are associated with MD area (cm2) change across age. We conducted a cohort study of 31 782 Swedish women ages 40-70 years at time of baseline mammogram. Lifestyle and reproductive risk factors were assessed by a web-based questionnaire. MD was measured as dense area using the STRATUS method (mean over the left and right breast). Linear regression analyses with adjustments for age, body mass index (BMI), and menopausal status at baseline were performed to assess the association between breast cancer risk factors and mean baseline MD. To investigate mean MD change across age, linear regression analyses with adjustments for age, BMI, menopausal status, and age at last mammogram were performed. All tests of statistical significance were two-sided. Except for oral contraceptive use, established lifestyle and reproductive risk factors for breast cancer were associated with baseline mean MD. The overall average annual MD change was -1.0 cm2. BMI and physical activity were statistically significantly associated with MD change. Lean women (BMI <20 kg/m2) had a mean MD change of -1.13 cm2 per year (95% confidence interval = -1....Continue Reading

References

Nov 1, 1995·Journal of the National Cancer Institute·C ByrneR Haile
Jul 7, 1994·The New England Journal of Medicine·M LambeH O Adami
Jan 1, 1993·Epidemiologic Reviews·A M Oza, N F Boyd
Feb 15, 2001·The New England Journal of Medicine·M Clemons, P Goss
Feb 15, 2001·JAMA : the Journal of the American Medical Association·C M RutterS Taplin
Jan 2, 2003·Journal of the National Cancer Institute·Gail A GreendaleGiske Ursin
Apr 22, 2004·Journal of the National Cancer Institute·Jack CuzickStephen W Duffy
Mar 1, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Tong LiNorman Boyd
Aug 13, 2005·Climacteric : the Journal of the International Menopause Society·J HarveyV V Ragavan
Sep 22, 2005·Journal of the National Cancer Institute·Anne McTiernanUNKNOWN Women's Health Initiative Mammogram Density Study Investigators
Apr 15, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gertraud MaskarinecLaurence N Kolonel
Jun 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Valerie A McCormack, Isabel dos Santos Silva
Nov 9, 2006·Menopause : the Journal of the North American Menopause Society·Janet R GuthrieHenry G Burger
Nov 23, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Norman F BoydSalomon Minkin
Jan 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yngve BremnesInger T Gram
Jan 19, 2007·The New England Journal of Medicine·Norman F BoydMartin J Yaffe
Mar 8, 2007·Journal of the National Cancer Institute·Karla KerlikowskeUNKNOWN National Institutes of Health Breast Cancer Surveillance Consortium
Jul 28, 2007·International Journal of Cancer. Journal International Du Cancer·Yngve BremnesInger T Gram
Apr 4, 2008·American Journal of Epidemiology·Linda E KelemenCeline M Vachon
May 10, 2008·Archives of Physiology and Biochemistry·Andrew G RenehanCaroline Dive
Jan 7, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Giske UrsinThomas Mack
Apr 1, 2010·American Journal of Epidemiology·Shannon M ConroyLaurel A Habel
May 18, 2010·The Lancet Oncology·UNKNOWN Endogenous Hormones and Breast Cancer Collaborative GroupAndrew W Roddam
Jul 10, 2010·Journal of the National Cancer Institute·Norman F BoydSalomon Minkin
Mar 29, 2011·Breast Cancer Research and Treatment·Joohon SungDonghun Lee
Nov 26, 2011·Breast Cancer Research : BCR·Norman F BoydSalomon Minkin
Feb 24, 2012·AJR. American Journal of Roentgenology·Cristina M CheckaHildegard Toth
Feb 23, 2013·Journal of Oncology·Amina AmadouIsabelle Romieu
Dec 19, 2013·PloS One·Judith S BrandFuat Celebioglu
Dec 10, 2015·Cancer Causes & Control : CCC·Katja Kemp JacobsenZorana J Andersen
May 18, 2016·European Journal of Epidemiology·Arvid Sjölander
Feb 10, 2017·International Journal of Epidemiology·Marike GabrielsonPer Hall

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Citations

Jul 13, 2019·Journal of the National Cancer Institute·Shadi AzamPer Hall
Sep 20, 2020·International Journal of Cancer. Journal International Du Cancer·Shadi AzamPer Hall
Aug 28, 2020·Breast Cancer Research : BCR·Marike GabrielsonPer Hall
May 16, 2020·Cancer Causes & Control : CCC·Ibrahem H KanbaytiErnest U Ekpo
Sep 26, 2020·International Journal of Cancer. Journal International Du Cancer·Pui San TanKamila Czene
Feb 19, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Russell B McBrideWeiva Sieh
Mar 18, 2021·Annals of African Medicine·Hadijat Oluseyi Kolade-Yunusa, Ukamaka Dorothy Itanyi

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