Determinants of methicillin-resistant Staphylococcus aureus (MRSA) prevalence in the Asia-Pacific region: A systematic review and meta-analysis

Journal of Global Antimicrobial Resistance
Wey Wen LimBenjamin J Cowling

Abstract

Published literature on methicillin-resistant Staphylococcus aureus (MRSA) in the Asia-Pacific region was reviewed to document the prevalence of MRSA in the region and to examine the impact of variability in study design on the reported MRSA prevalence data. This review included studies reporting MRSA prevalence between 2000 and 2016. Studies were excluded if they did not contain complete information on antimicrobial susceptibility testing (AST) methods. Primary outcomes were the proportion of MRSA among S. aureus isolates (resistance proportion) or among individual samples (prevalence). A total of 229 studies in 19 countries/territories were included in the study. There was substantial heterogeneity in both outcomes (resistance proportion, I2=99.59%; prevalence, I2=99.83%), precluding pooled averages, and meta-regression analyses revealed that these variations were explained by country income status and participant characteristics but not by methodological differences in AST. Also, no significant secular changes in MRSA prevalence or resistance proportions in Asia-Pacific were found. The resistance proportions and prevalence of MRSA infections in Asia-Pacific are comparable with those reported in other regions with no signific...Continue Reading

Citations

May 15, 2020·Clinical Microbiology Reviews·David M P De OliveiraMark J Walker
Apr 14, 2020·JAC-antimicrobial Resistance·Sukhyun RyuYonatan H Grad
Nov 21, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Ashok KhanalSuresh Panthee
Dec 30, 2020·Proceedings of the National Academy of Sciences of the United States of America·Rik OldenkampAntonio Cappuccio

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