Determinants of methotrexate adherence in rheumatoid arthritis patients

Clinical Rheumatology
Ellen De CuyperLuc S De Clerck

Abstract

In rheumatoid arthritis (RA) patients, weekly intake of methotrexate (MTX) is the basic drug treatment. This observational study aims to investigate how many RA patients are adherent in terms of MTX intake and to identify determinants of non-adherence. Intake of MTX (orally or via injection) was recorded in 129 RA patients with an electronic monitoring system (MEMS(®)) during 16 weeks. In addition, two adherence questionnaires, the Medication Adherence Report Scale (MARS-5) and the Compliance-Questionnaire-Rheumatology (CQR) as well as a visual analogue scale (VAS) measuring MTX adherence, were administered to these patients. As possible determinants of adherence, data on demographics, disease and treatment characteristics, depression, illness cognitions, motivation, and social support were collected. Of all participants, 58 % were fully adherent and 75 % skipped at most one dose during 16 weeks. A better mental health status and suffering from comorbidities had a positive effect on adherence, while living alone had a negative effect. These three predictors explained 30 % of the variance in MTX adherence. Of the three self-report medication adherence measures, the VAS correlated the highest with the results of the electronic mo...Continue Reading

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Citations

Mar 30, 2019·International Journal of Rheumatic Diseases·Parvaneh HeidariKimberley Crawford
Nov 27, 2019·Clinical Rheumatology·Clélia MonchablonThierry Lequerré
Nov 3, 2016·The Journal of Rheumatology·Jeffrey R CurtisMichael Schiff
Feb 4, 2021·Patient Preference and Adherence·Manuel Pombo-SuarezJuan Jesus Gomez-Reino
Apr 8, 2021·Drug, Healthcare and Patient Safety·Jesús Tornero MolinaNúria Casamira Ruiz

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