PMID: 15344210Sep 3, 2004Paper

Determinants of one-year response of lumbar bone mineral density to alendronate treatment in elderly Japanese women with osteoporosis

Yonsei Medical Journal
Jun IwamotoMitsuyoshi Uzawa

Abstract

The purpose of this study was to determine factors that could predict the one-year response of the lumbar bone mineral density (BMD) to alendronate treatment in elderly Japanese women with osteoporosis. Eighty-five postmenopausal women with osteoporosis, all of whom were between 55-88 years of age, were treated with alendronate (5 mg daily) for 12 months. Serum calcium, phosphorus, and alkaline phosphatase (ALP) and urinary NTX levels were measured at the baseline and 6 months, and lumbar (L1-L4) BMD was measured by dual energy X-ray absorptiometry at the baseline and 12 months. Multiple regression analysis was used to determine factors that were correlated with the percent change in lumbar BMD at 12 months. Lumbar BMD increased by 8.1 % at 12 months with a reduction in the urinary NTX level by 51.0 % at 6 months. Baseline lumbar BMD (R2=0.226, p < 0.0001) and percent changes in serum ALP and urinary NTX levels (R2=0.044, p < 0.05 and R2=0.103, p < 0.001, respectively) had a negative correlation with the percent change in lumbar BMD at month 12, while the baseline number of prevalent vertebral fractures (R2=0.163, p < 0.001), serum ALP level, and urinary NTX level (R2=0.074, p < 0.05 and R2=0.160, p < 0.001, respectively) had a...Continue Reading

Citations

May 14, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J ColletteJ-Y Reginster
Nov 26, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J IwamotoH Matsumoto
Mar 18, 2011·Critical Reviews in Oncology/hematology·Robert ColemanAllan Lipton
May 2, 2013·Menopause : the Journal of the North American Menopause Society·John Christopher GallagherArkadi A Chines
Sep 4, 2015·Calcified Tissue International·Le T DuongBente Langdahl
May 10, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Margaret E Tanzy, Pauline M Camacho
Feb 7, 2008·The Cochrane Database of Systematic Reviews·G A WellsP Tugwell
Aug 29, 2007·Journal of Aging and Physical Activity·Panagiota KlentrouMichael Ladouceur

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