Determinants of ovine compact bone viscoelastic properties: effects of architecture, mineralization, and remodeling

Bone
C M LesD P Fyhrie

Abstract

Significant decreases in ovine compact bone viscoelastic properties (specifically, stress-rate sensitivity, and damping efficiency) are associated with three years of ovariectomy and are particularly evident at higher frequencies [Proc. Orthop. Res. Soc. 27 (2002) 89]. It is unclear what materials or architectural features of bone are responsible for either the viscoelastic properties themselves, or for the changes in those properties that were observed with estrogen depletion. In this study, we examined the relationship between these viscoelastic mechanical properties and features involving bone architecture (BV/TV), materials parameters (ash density, %mineralization), and histologic evidence of remodeling (%remodeled, cement line interface). The extent of mineralization was inversely proportional to the material's efficiency in damping stress oscillations. The damping characteristics of bone material from ovariectomized animals were significantly more sensitive to variation in mineralization than was bone from control animals. At low frequencies (6 Hz or less), increased histologic evidence of remodeling was positively correlated with increased damping efficiency. However, the dramatic decreases in stress-rate sensitivity tha...Continue Reading

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Citations

Apr 8, 2010·Journal of Biomechanical Engineering·Do-Gyoon KimSarah Hueni
Jul 3, 2015·Experimental and Therapeutic Medicine·Zhifeng YuKerong Dai
May 7, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Xiao YangTaeyong Lee
Nov 7, 2012·Journal of the Mechanical Behavior of Biomedical Materials·Xiuli ChenTaeyong Lee
Mar 23, 2012·The Journal of Investigative Dermatology·Ming FangMark M Banaszak Holl
Jul 19, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C M LesD P Fyhrie
Jul 23, 2005·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·John G SkedrosRoy D Bloebaum
Feb 14, 2007·Journal of Biomedical Materials Research. Part a·Yener N YeniDavid P Fyhrie
May 26, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·John G SkedrosJoshua D Holyoak
Nov 5, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ziheng WuGlen L Niebur
Mar 1, 2011·Journal of Biomechanics·Ziheng WuGlen L Niebur
Feb 8, 2006·Clinical Orthopaedics and Related Research·Yener N YeniDavid P Fyhrie
Nov 18, 2018·Scientific Reports·Diarra K WilliamsDana Gaddy
Feb 27, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Fan FanQuentin Grimal

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