Determinants of parathyroid hormone response to vitamin D supplementation: a systematic review and meta-analysis of randomised controlled trials

The British Journal of Nutrition
Nazanin MoslehiFereidoun Azizi

Abstract

This systematic review aimed to assess the determinants of the parathyroid hormone (PTH) level response to vitamin D supplementation. We searched Medline, Google Scholar and the reference lists of previous reviews. All randomised controlled trials (RCT) on vitamin D supplementation that involved apparently healthy human subjects with a report of PTH were selected. Potential studies were screened independently and in duplicate. Results are summarised as mean differences with 95% confidence intervals. Quality assessment, subgroup analysis, meta-analysis and meta-regression analysis were carried out. Thirty-three vitamin D supplementation RCT were included. Vitamin D supplementation significantly raised circulating 25-hydroxyvitamin D (25(OH)D) with significant heterogeneity among studies with a pooled mean difference (PMD) of 15.5 ng/ml (test for heterogeneity: P<0·001 and I 2=97·3%). Vitamin D supplementation significantly reduced PTH level with PMD of -8·0 pg/ml, with significant heterogeneity ((test for heterogeneity: P<0·001) and the I 2 value was 97·3%). In the subgroup analyses, the optimum treatment effect for PTH was observed with Ca doses of 600-1200 mg/d (-22·48 pg/ml), after the duration of a >12-month trial (-18·36 pg...Continue Reading

References

Dec 3, 1992·The New England Journal of Medicine·M C ChapuyP J Meunier
Jul 23, 1992·The New England Journal of Medicine·J LauT C Chalmers
Feb 1, 1991·Journal of the American Geriatrics Society·F M GlothB W Hollis
Nov 4, 1989·Lancet·M F HolickJ Wortsman
Jul 1, 1985·The Journal of Clinical Investigation·N H BellS Shaw
Oct 1, 1985·The Journal of Clinical Investigation·J MacLaughlin, M F Holick
Aug 1, 1987·The American Journal of Clinical Nutrition·M C ChapuyP J Meunier
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Aug 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M E OomsL M Bouter
Feb 1, 1996·Controlled Clinical Trials·A R JadadH J McQuay
Sep 4, 1997·The New England Journal of Medicine·B Dawson-HughesG E Dallal
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Oct 15, 1998·The American Journal of Clinical Nutrition·H M TrangR Vieth
Jan 14, 1999·The New England Journal of Medicine·J A BaronE R Greenberg
Sep 1, 2000·The American Journal of Clinical Nutrition·J WortsmanM F Holick
Sep 27, 2000·Journal of Clinical Epidemiology·D MoherA Liberati
Nov 25, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D HunterT D Spector
Mar 27, 2002·International Journal of Epidemiology·Peter JüniMatthias Egger
Aug 9, 2002·Journal of the American College of Nutrition·Susan S Harris, Bess Dawson-Hughes
Dec 25, 2002·The American Journal of Clinical Nutrition·Robert P HeaneyM Janet Barger-Lux
Feb 6, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Heike A BischoffMartin Conzelmann
May 6, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C J BatesA Prentice
Dec 23, 2003·Journal of the American Geriatrics Society·Anne M KennyJoseph A Burleson
Jul 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Paul Lips
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Laura A G ArmasRobert P Heaney
Dec 9, 2004·The American Journal of Clinical Nutrition·Connie M Weaver, James C Fleet
Mar 19, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Bess Dawson-HughesReinhold Vieth
Apr 28, 2005·The Journal of Clinical Endocrinology and Metabolism·Marieke B SnijderPaul Lips
Nov 10, 2005·JAMA : the Journal of the American Medical Association·Laufey SteingrimsdottirGunnar Sigurdsson
Aug 16, 2006·Current Osteoporosis Reports·Michael F Holick
Sep 9, 2006·The American Journal of Clinical Nutrition·John F AloiaJames K Yeh
Oct 13, 2006·Journal of the American College of Nutrition·Heli T ViljakainenChristel Lamberg-Allardt
Mar 9, 2007·The American Journal of Clinical Nutrition·Reinhold ViethArmin Zittermann
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Sep 18, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V ChelP Lips
Feb 5, 2008·Archives of Gerontology and Geriatrics·Mikko BjörkmanRejo Tilvis

❮ Previous
Next ❯

Citations

May 7, 2016·Nature Reviews. Cardiology·Stefan PilzWinfried März
Feb 9, 2019·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Maryam TaheriAbbas Basiri
Feb 14, 2020·Cancer Causes & Control : CCC·Hanseul KimEdward Giovannucci
Jun 28, 2018·European Journal of Nutrition·Christian TrummerElisabeth Lerchbaum
Oct 25, 2016·International Journal of Environmental Research and Public Health·Christian TrummerVerena Schwetz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.