PMID: 9425328Jan 13, 1998Paper

Determinants of positive histologic margins and residual tumor after lumpectomy for early breast cancer: a prospective study with special reference to touch preparation cytology

Journal of Surgical Oncology
A O SaarelaH O Kiviniemi

Abstract

Removal of the entire tumor by breast-conserving surgery is important, but the determinants of adequate excision have not been established. A prospective study of 55 consecutive lumpectomies for early breast cancer was performed to study the correlation between touch preparation cytology and histologic margins and the determinants of positive histologic margins and residual disease after the initial excision. The correlation between touch preparation cytology and histologic margins was poor: sensitivity and specificity were 37.5% and 85.1%, respectively. The histologic margins were positive in 8 cases (14.5%) and were related to the presence of intraductal carcinoma and to the large pathologic size of the index tumor. Re-excision specimen of the tumor bed (34 of 55 cases) contained residual cancer in seven cases (20.6%). Multifocal and nonpalpable index tumors predicted residual cancer. Residual disease was found in 37.5% of the cases (3 of 8) with positive and in 15.4% of the cases (4 of 26) with negative histologic margins. Touch preparation cytology cannot be recommended as a method of assessing lumpectomy margins for early breast cancer. Histologic margins are misleading in predicting residual cancer in re-excision specimen...Continue Reading

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Citations

Aug 7, 2013·Breast Cancer Research : BCR·Ashley M LaughneyWendy A Wells
Jun 12, 2009·The Breast : Official Journal of the European Society of Mastology·François D'HalluinJean Levêque
Jul 9, 2005·Clinical Breast Cancer·Norma RodriguezElizabeth L Wiley
Sep 13, 2003·The Breast Journal·John D HenleyHarvey M Cramer
Mar 3, 2006·The Breast Journal·Chrisoula D ScopaChristina Aletra
Sep 1, 2004·International Journal of Radiation Oncology, Biology, Physics·Frank A ViciniLarry L Kestin
Nov 15, 2001·Advances in Anatomic Pathology·E K Millar, A S Leong
Feb 11, 2016·World Journal of Clinical Oncology·José H VoldersPetrousjka M van den Tol
Jan 9, 2007·Annals of Surgical Oncology·Edna K ValdesSheldon M Feldman
Jan 28, 2003·The American Journal of Surgical Pathology·Elizabeth L WileyMonica Morrow
Aug 22, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ashley M LaughneyWendy A Wells
Jun 29, 2002·Archives of Pathology & Laboratory Medicine·Andrew J CreagerKim R Geisinger

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