Determinants of real-world functional performance in schizophrenia subjects: correlations with cognition, functional capacity, and symptoms

The American Journal of Psychiatry
Christopher R BowiePhilip D Harvey

Abstract

Impairments in adaptive life skills are a major source of disability in patients with schizophrenia. The relationship between adaptive life skills in real-world settings and performance on neuropsychological tests may be complicated by other factors that interfere with deployment of skills. Assessment of the ability to perform life skills under optimal conditions (i.e., assessment of functional capacity) has been proposed as a means to clarify these relationships. The authors examined cross-sectional data from a study of the course of neuropsychological and adaptive life skills of older (age 50-85) schizophrenia patients (N=78). Functional capacity was examined with a performance-based measure (UCSD Performance-Based Skills Assessment), and case managers rated real-world adaptive functions (i.e., interpersonal skills, work skills, and community activities). Neuropsychological performance was assessed with a comprehensive battery, while symptoms were assessed with patient self-report and clinical ratings. Confirmatory path analyses were used to evaluate the effects of neuropsychological performance, functional capacity, and symptoms on the various domains of real-world functioning. Neuropsychological performance predicted functi...Continue Reading

Citations

Nov 26, 2008·Social Psychiatry and Psychiatric Epidemiology·Sheilagh HodginsTim Mak
Oct 15, 2009·European Archives of Psychiatry and Clinical Neuroscience·Silvana GalderisiMario Maj
Mar 9, 2011·European Archives of Psychiatry and Clinical Neuroscience·Sofia BrissosMaria Luisa Figueira
Dec 13, 2006·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Margaret M McClureLarry J Siever
Nov 13, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ofer AgidGary Remington
Dec 12, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Stephen Z Levine, Stefan Leucht
Jun 19, 2013·Psychiatry Research·Frederik M van der VeenMarion Smits
Oct 30, 2012·Psychiatry Research·Pilar Lopez-GarciaFelipe Ortuño Sanchez-Pedreño
Sep 16, 2009·Psychological Medicine·C González-BlanchB Crespo-Facorro
May 21, 2010·Psychological Medicine·Y RassovskyM F Green
Mar 26, 2013·Psychological Medicine·D W JoyceS S Shergill
Oct 19, 2007·Journal of the International Neuropsychological Society : JINS·Barton W Palmer, Gauri N Savla
Apr 19, 2008·Journal of the International Neuropsychological Society : JINS·Winnie W LeungPhilip D Harvey
Nov 11, 2009·Journal of the International Neuropsychological Society : JINS·Frank LarøiMartial VAN DER Linden
Jun 1, 2010·Journal of the International Neuropsychological Society : JINS·Carmen SimonsenOle A Andreassen
Feb 22, 2013·Journal of the International Neuropsychological Society : JINS·Philip D HarveyThomas L Patterson
Nov 15, 2012·Psychological Assessment·Raeanne C MooreBrent T Mausbach
Jan 22, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Terry E GoldbergPhilip D Harvey
May 10, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Donald C GoffSteven A Johnson
Aug 11, 2007·Cognitive Neuropsychiatry·Christian G KohlerRuben C Gur
Aug 23, 2008·Journal of Clinical and Experimental Neuropsychology·Philip D HarveyChristopher R Bowie
Aug 18, 2009·Journal of Clinical and Experimental Neuropsychology·Allen E ThorntonWendy Loken Thornton
May 11, 2010·Journal of Clinical and Experimental Neuropsychology·Steven M SilversteinGersham Dent
Jan 26, 2012·Journal of Clinical and Experimental Neuropsychology·Felicia GouldPhilip D Harvey
May 19, 2011·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Anne-Claire LarochetteChristopher R Bowie
Dec 14, 2006·Schizophrenia Bulletin·Dwight DickinsonJames M Gold
Mar 8, 2007·Schizophrenia Bulletin·Brent T MausbachThomas L Patterson
May 12, 2007·Schizophrenia Bulletin·Philip D HarveyAlan S Bellack
Jun 15, 2007·Schizophrenia Bulletin·Richard S E Keefe, Wayne S Fenton
Jul 23, 2008·Schizophrenia Bulletin·George Foussias, Gary Remington
Aug 1, 2008·Schizophrenia Bulletin·R Walter HeinrichsStephanie McDermid Vaz
Nov 22, 2008·Schizophrenia Bulletin·Brent T MausbachThomas L Patterson
Jun 16, 2009·Schizophrenia Bulletin·Feea R LeifkerPhilip D Harvey
Feb 14, 2012·Schizophrenia Bulletin·Veronica CardenasBrent T Mausbach
Dec 8, 2010·The Journal of Nervous and Mental Disease·Denisse TiznadoThomas L Patterson
Mar 12, 2008·Current Opinion in Psychiatry·Robin EmsleyRenata Schoeman
Oct 15, 2008·Current Opinion in Psychiatry·Georg Juckel, Pier Luigi Morosini
Jan 7, 2010·Current Opinion in Psychiatry·Georg Winterer
Apr 25, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Sheilagh Hodgins

❮ Previous
Next ❯

Software Mentioned

SPSS
AMOS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.