Determinants of response to triple therapy of telaprevir, peginterferon, and ribavirin in previous non-responders infected with HCV genotype 1

Journal of Medical Virology
Norio AkutaH Kumada

Abstract

Patients who do not achieve sustained virological response to telaprevir/peginterferon (PEG-IFN)/ribavirin need to be identified. Predictive factors of virological response to the triple therapy in non-responders to previous PEG-IFN/ribavirin therapy are not clear. The aims of this study were to determine the predictive factors of virological response to a 24-week regimen of triple therapy in 15 non-responders to previous PEG-IFN/ribavirin therapy among 61 Japanese adults infected with HCV genotype 1. Overall, sustained virological response and end-of-treatment response were achieved by 27% and 60%, respectively. Telaprevir-resistant variants (by direct sequencing) appeared during or after treatment in 82% of patients who did not show sustained virological response, but disappeared at the end of study, except for one patient with resistant variant at baseline. Substitution at aa 70 (Arg70) and type of previous response to PEG-IFN/ribavirin (partial response) were identified as significant determinants of sustained virological response. In addition, alpha-fetoprotein level (<10 µg/L) and type of previous response (partial response) were identified as significant determinants of end-of-treatment response. Prediction of response t...Continue Reading

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Citations

May 9, 2014·International Journal of Nanomedicine·Chen-Hua Liu, Jia-Horng Kao
Nov 29, 2012·Journal of Gastroenterology·Kazuaki ChayamaYoshiiku Kawakami
Jun 19, 2013·Asian Pacific Journal of Tropical Medicine·A RafieiA Makhlough
Jul 26, 2014·Expert Review of Anti-infective Therapy·Namiki Izumi

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