Determinants of retinal microvascular features and their relationships in two European populations

Journal of Hypertension
Mirna KirinVeronique Vitart

Abstract

To examine factors influencing retinal vasculature in two environmentally contrasted, cross-sectional studies of adult participants of European descent and to estimate the extent and specificity of genetic contributions to each retinal vasculature feature. Retinal images from 1088 participants in the Orkney Complex Disease Study and 387 in the CROATIA-Korčula study, taken using the same nonmydriatic camera system and graded by the same person, were evaluated. Using general linear models, we estimated the influence of an extensive range of systemic risk factors, calculated retinal traits heritabilities and genetic correlations. Systemic covariates explained little (<4%) of the variation in vessel tortuosity, substantially more (>10%, up to 31.7%) of the variation in vessel width and monofractal dimension. Suggestive not well trodden associations of biological interest included that of urate, tissue plasminogen activator and cardiac PR interval with arteriolar narrowing, that of carotid intima-media thickness with less-tortuous arterioles and of cardiac QT interval with more tortuous venules. The genetic underpinning of tortuosity is largely distinct from that of the other retinal vascular features, whereas that of fractal dimens...Continue Reading

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Citations

Jul 30, 2020·Obesity·Robyn J TappUNKNOWN UK Biobank Eye, Vision Consortium
Oct 11, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Abirami VeluchamyAlexander S F Doney
May 20, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Mengjiao LiuMelissa Wake
Jun 4, 2019·Investigative Ophthalmology & Visual Science·Louis ArnouldCatherine Creuzot-Garcher
Aug 31, 2019·Schizophrenia Research·Abhishek AppajiNaren P Rao

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Methods Mentioned

BETA
genotyping

Software Mentioned

CardioView
GenABEL
SIVA
PEDSTATS
nortest
Genome Studio ( Hap / Omni )
GenABEL R package
SOLAR
CROATIA
Hmisc R package

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