Determinants of rifabutin-associated uveitis in patients treated with rifabutin, clarithromycin, and ethambutol for Mycobacterium avium complex bacteremia: a multivariate analysis. Canadian HIV Trials Network Protocol 010 Study Group

The Journal of Infectious Diseases
S D ShafranW F Schlech

Abstract

Uveitis occurred in a substantial proportion of AIDS patients receiving rifabutin, 600 mg daily, together with clarithromycin and ethambutol for treatment of Mycobacterium avium complex bacteremia. A case-control study was undertaken to examine potential risk factors for developing uveitis. Of eight parameters examined, only baseline body weight predicted the development of uveitis by both univariate and multivariate analyses (P = .001). The incidence of uveitis was 14% in patients weighing >65 kg, 45% in patients between 55 and 65 kg, and 64% in patients <55 kg. Concomitant therapy with fluconazole, a drug known to raise serum rifabutin concentrations, was not associated with an increased incidence of uveitis. The risk of uveitis was markedly reduced when rifabutin was given at 300 mg daily in combination with clarithromycin and ethambutol.

Citations

Feb 9, 2012·Journal of Ophthalmic Inflammation and Infection·Wendy M SmithH Nida Sen
Nov 12, 2005·The Pediatric Infectious Disease Journal·Hanne Hyldahl Olesen, Susanne Krag
Mar 26, 2013·Journal of Ophthalmic Inflammation and Infection·Nikolas Js LondonEmmett T Cunningham
Aug 5, 2014·Journal français d'ophtalmologie·C Pochat-CotillouxL Kodjikian
Aug 23, 2005·Expert Opinion on Drug Safety·Giovanni Di PerriStefano Bonora
Oct 18, 2014·Expert Opinion on Drug Safety·Miguel Cordero-ComaTaygan Yilmaz
Feb 20, 2008·American Journal of Ophthalmology·Gary N Holland
Mar 25, 2016·The Journal of Antimicrobial Chemotherapy·Yoann CrabolOlivier Lortholary
Dec 22, 2006·Expert Review of Anti-infective Therapy·Jason E Stout
Sep 18, 2018·Current Opinion in Ophthalmology·Ramana S MoorthyEmmett T Cunningham
Mar 29, 2007·Journal of the Chinese Medical Association : JCMA·Hsin-Hui WangWing-Wai Wong
Apr 24, 2007·International Ophthalmology Clinics·Rasha AliBonnie An Henderson
Jul 19, 2019·Journal of the International AIDS Society·Neesha RockwoodAnton L Pozniak
Oct 9, 2013·Current Opinion in Ophthalmology·Ramana S MoorthyEmmett T Cunningham
Mar 3, 2015·International Ophthalmology Clinics·Jane M Wells, Justine R Smith
Dec 19, 2019·Ocular Immunology and Inflammation·Ilaria TestiVishali Gupta
Aug 23, 2020·Indian Journal of Ophthalmology·Manisha AgarwalBahram Bodaghi
Feb 22, 2021·Vestnik oftalmologii·O D OstroumovaL K Moshetova
Apr 22, 2017·Microbiology Spectrum·Charles L Daley
Jul 14, 2021·Ocular Immunology and Inflammation·Imen KsiaaMoncef Khairallah

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.