PMID: 9547469Apr 21, 1998Paper

Determinants of spontaneous extrapyramidal symptoms in elderly psychiatric inpatients diagnosed with Alzheimer's disease, major depressive disorder, or psychotic disorders

The Journal of Neuropsychiatry and Clinical Neurosciences
R A SweetG S Zubenko

Abstract

Extrapyramidal symptoms (EPS) occur more frequently in dementia of the Alzheimer's type (DAT) than in normal aging. Other late-life mental disorders, however, have also been associated with EPS. To examine whether EPS are increased in DAT patients relative to neuropsychiatric control subjects, the authors compared EPS in 127 neuroleptic-free elderly patients diagnosed with either DAT, major depressive disorder (MDD), or a psychotic disorder (SCHIZ/DELUS). They also examined whether depressive or psychotic symptoms were associated with EPS independently of diagnosis. Severity of parkinsonian rigidity was found to be independently associated with DAT. Rank order of rigidity was DAT > MDD > SCHIZ/DELUS. Bradykinesia, although not associated with diagnostic group, was positively correlated with withdrawn depression. These findings suggest that rigidity is associated with DAT independently of any concurrent psychotic or depressive process, whereas bradykinesia does not appear to be specific to DAT among late-life neuropsychiatric illnesses.

Citations

Apr 1, 2003·Current Therapeutic Research, Clinical and Experimental·George T Grossberg
Jul 26, 2000·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·D C MamoC F Reynolds
Apr 2, 2002·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·David C MamoCharles F Reynolds III
Aug 18, 2006·Journal of Geriatric Physical Therapy·Johannes S M HobbelenRob A de Bie
Apr 19, 2000·Journal of Clinical Psychopharmacology·R A SweetM A DeMichele

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
A KumarG Gottlieb
The American Journal of Psychiatry
S ZisookD V Jeste
The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Helen LavretskyAnand Kumar
The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Helen LavretskyAnand Kumar
© 2022 Meta ULC. All rights reserved