Determinants of surgical resection for pancreatic neuroendocrine tumors

Journal of Hepato-biliary-pancreatic Sciences
Ryuichiro Doi

Abstract

Pancreatic neuroendocrine tumors (pNETs) include functioning and non-functional tumors. Functioning tumors consist of tumors that produce a variety of hormones and their clinical effects. Therefore, determinants of resection of pNETs should be discussed for each group of tumors. Less than 10% of insulinomas are malignant, therefore more than 90% of the cases can be cured by surgical resection. Lymphadenectomy is generally not necessary in insulinoma operation. If preoperative localization of the insulinoma is completed, enucleation from the pancreatic body or tail, and distal pancreatectomy can be performed safely by laparoscopy. When preoperative localization of a sporadic insulinoma is not confirmed, surgical exploration is needed. Intraoperative localization of a tumor, intraoperative insulin sampling and frozen section are required. The crucial purpose of surgical resection is to control inappropriate insulin secretion by removing all insulinomas. Gastrinomas are usually located in the duodenum or pancreas, which secrete gastrin and cause Zollinger-Ellison syndrome (ZES). Duodenal gastrinomas are usually small, therefore they are not seen on preoperative imaging studies or endoscopic ultrasound, and can be found only at sur...Continue Reading

References

Jan 1, 1995·American Journal of Surgery·F G QueL K Kvols
Sep 1, 1994·Annals of Surgery·D L FrakerR T Jensen
Jul 11, 1998·Journal of the American College of Surgeons·H ChenM A Choti
Aug 26, 1999·The New England Journal of Medicine·J A NortonR T Jensen
Jan 8, 2000·The New England Journal of Medicine·B I Hirschowitz
Apr 11, 2000·Journal of the American College of Surgeons·R S ChamberlainL H Blumgart
May 2, 2003·Annals of Surgery·Alan W HemmingJean-Nicolas Vauthey
May 9, 2003·Surgical Oncology Clinics of North America·Juan M Sarmiento, Florencia G Que
Jul 2, 2003·Journal of the American College of Surgeons·Juan M SarmientoFlorencia G Que
Aug 28, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Cengizhan YigitlerJacques Belghiti
Apr 16, 2004·Pancreas·Ryuichiro DoiMasayuki Imamura
Feb 22, 2005·American Journal of Surgery·Gerard V Aranha, Margo Shoup
Apr 2, 2005·Current Gastroenterology Reports·Fathia Gibril, Robert T Jensen
Apr 26, 2005·Annals of Surgery·John G TouziosHenry A Pitt
Feb 3, 2006·Journal of the National Comprehensive Cancer Network : JNCCN·Jeffrey A NortonRobert T Jensen
Mar 2, 2006·Cancer Control : Journal of the Moffitt Cancer Center·Pamela HodulLarry Kvols
May 9, 2006·World Journal of Surgery·Maria A KouvarakiNancy D Perrier
May 16, 2006·The American Journal of Surgical Pathology·Martin AnlaufGünter Klöppel
Aug 24, 2006·Annals of Surgery·Jeffrey A NortonRobert T Jensen
Feb 22, 2007·Neuroendocrinology·Robert T JensenUNKNOWN European Neuroendocrine Tumor Society
Feb 22, 2007·Neuroendocrinology·Wouter W de HerderUNKNOWN European Neuroendocrine Tumor Society
Feb 22, 2007·Neuroendocrinology·Dermot O'TooleUNKNOWN European Neuroendocrine Tumor Society
Feb 22, 2007·Neuroendocrinology·Massimo FalconiUNKNOWN European Neuroendocrine Tumor Society
Mar 27, 2007·Best Practice & Research. Clinical Endocrinology & Metabolism·Göran Akerström, Per Hellman
Nov 2, 2007·Journal of the American College of Surgeons·Jeffrey A Norton, Robert T Jensen
Oct 17, 2007·The British Journal of Surgery·V FendrichM Rothmund
Nov 7, 2007·Wiener klinische Wochenschrift·Kerstin Lorenz, Henning Dralle
Nov 7, 2007·Wiener klinische Wochenschrift·Detlef K BartschMatthias Rothmund
Nov 28, 2007·The British Journal of Surgery·M FalconiP Pederzoli
Feb 12, 2008·World Journal of Surgery·Laureano Fernández-CruzHéctor Rendón

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Citations

Jul 23, 2015·Journal of Hepato-biliary-pancreatic Sciences·Tetsuhide Ito
Aug 22, 2015·Case Reports in Surgery·Ersin BorazanAhmet Abdulhalik Balik
Jul 28, 2016·Cirugía española·Francisco Sánchez-BuenoPascual Parrilla Paricio
Nov 11, 2017·BMC Surgery·Gian Piero GuerriniFabrizio Di Benedetto
Aug 8, 2017·Journal of Minimal Access Surgery·Abhay Narendra DalviNalini Samir Shah
Sep 14, 2016·Korean Journal of Hepato-biliary-pancreatic Surgery·Michail PapamichailNigel Heaton
Mar 7, 2020·Scientific Reports·Francesco CollamatiRiccardo Faccini
Dec 16, 2016·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Jose L Ulla RochaElena Gallardo

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