PMID: 9523523Apr 2, 1998Paper

Determinants of survival following hepatic resection for metastatic colorectal cancer

World Journal of Surgery
E A BakalakosE W Martin

Abstract

Hepatic resection remains the only potentially curative treatment for metastatic colorectal cancer. This retrospective review study was undertaken in an attempt to identify factors that influence patient survival following hepatic resection for metastatic colorectal cancer. From January 1978 to December 1993, a total of 301 patients underwent a total of 345 planned hepatic resections for metastatic colorectal cancer. Of those, 245 patients had one resection, 44 had two resections, and 12 had three resections. For all patients the overall median survival was 20.6 months, operative mortality was 1.1%, and overall morbidity was 17.2%. Average hospital stay was 9 days. Statistical analysis included univariate analysis using log rank comparisons, Kaplan-Meier survival curves, and multivariate analysis using Cox proportional hazards regression. The statistically significant factors that influenced survival were distribution of liver metastases, unilobar versus bilobar (p = 0.0001), resected versus nonresected (p < 0.0001), and tumor-free surgical margins versus positive margins (p = 0.001). Surprisingly, the disease-free interval and the original stage of the primary tumor did not predict survival (p = not significant). Other factors...Continue Reading

Citations

Mar 20, 2002·Cancer·Bradford J WoodStephen K Libutti
Jan 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A Marcos
May 27, 2005·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·W O Bechstein, M Golling
Dec 2, 2005·Langenbeck's Archives of Surgery·Hiroshi ShimadaShinji Togo
Dec 25, 2009·International Journal of Computer Assisted Radiology and Surgery·Thomas LangePeter M Schlag
Aug 8, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Srinevas K ReddyBryan M Clary
May 9, 2003·Surgical Oncology Clinics of North America·Annelore Altendorf-Hofmann, Johannes Scheele
Sep 3, 1999·Journal of the American College of Surgeons·S IwatsukiT E Starzl
Sep 6, 2000·The British Journal of Surgery·M S Rodgers, J L McCall
Mar 22, 2002·ANZ Journal of Surgery·Paul MorozBruce N Gray
Jun 7, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M A Memon, I J Beckingham
Oct 28, 2005·BMC Cancer·Wayne S Kendal
Oct 1, 2009·World Journal of Surgical Oncology·Sherif Raafat Zikry Abdel-MisihPaul Mark Bloomston
Sep 30, 2006·Annals of Surgical Oncology·Zaed Z R HamadyJ Peter A Lodge
Jun 10, 2009·Annals of Surgical Oncology·Srinevas K ReddyBryan M Clary
Jan 6, 2012·Annals of Surgical Oncology·Lichao SunYuliang Ran
Oct 17, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Shirali PatelD Rohan Jeyarajah
Nov 7, 2006·Annals of Surgical Oncology·B WieringT J M Ruers
Nov 15, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·L SpeltR Andersson
Mar 18, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Héctor Daniel González, Joan Figueras
Mar 8, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A SerrabloC Hörndler
Jul 16, 2008·Journal of Surgical Oncology·Atsushi NanashimaTerumitsu Sawai
Jan 13, 2016·International Journal of Cancer. Journal International Du Cancer·Lichao SunYuliang Ran
Nov 9, 2005·International Journal of Radiation Oncology, Biology, Physics·Subir NagEdward W Martin
May 9, 2003·Surgical Oncology Clinics of North America·Guido Torzilli, Masatoshi Makuuchi
Jan 9, 2003·Clinics in Liver Disease·Renuka BhattacharyaKris V Kowdley
Jun 28, 2011·The American Journal of Pathology·Lichao SunYuliang Ran

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.