Determinants of the blood pressure response to the first dose of ACE inhibitor in mild to moderate congestive heart failure

British Journal of Clinical Pharmacology
L MurrayK R Lees

Abstract

To investigate the relationship in patients with heart failure between BP response to the first dose of ACE inhibitor and (1) plasma drug concentration and (2) baseline clinical and laboratory variables. We studied individual placebo-corrected BP responses to initiation of treatment with one of a number ACE inhibitor preparations in 132 patients with mild to moderate CHF. Various pharmacokinetic/pharmacodynamic models were compared. We assessed the strength of association between baseline physiological and laboratory variables and the BP response as assessed directly from the AUC(0,10 h) and indirectly from the slope of the PK/PD relationship. Predictive models for response variables were developing using regression analysis. BP response was primarily related to plasma drug concentration. The association between the fall in BP and baseline variables was weak. The strongest single predictor of BP response was baseline mean arterial pressure (r2 = 5.8%, P = 0.02). The best combinations of predictor variables contained mean arterial pressure, plasma renin activity, creatinine concentration and age (r2 = 14.4%, P = 0.37). When the choice of ACE inhibitor was added, the predictive power of the model increased (r = 23.6%, P < 0.01) b...Continue Reading

References

Apr 1, 1978·Journal of Pharmacokinetics and Biopharmaceutics·K YamaokaT Uno
Oct 1, 1991·British Heart Journal·J G Cleland, C M Oakley
Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
Nov 9, 1985·British Medical Journal·J G ClelandI Ford
Oct 2, 1986·The New England Journal of Medicine·M PackerN Medina
Jan 1, 1987·Cardiovascular Drugs and Therapy·W P Leary, A J Reyes
Jul 1, 1971·Biochemical Pharmacology·D W Cushman, H S Cheung
Mar 12, 1983·British Medical Journal·G P HodsmanJ I Robertson

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Citations

Jul 29, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·J S Cohen

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