Determinants of the renin-angiotensin-aldosterone system in cirrhosis with special emphasis on the central blood volume

Scandinavian Journal of Gastroenterology
Søren MøllerJens H Henriksen

Abstract

Several studies have shown activation of the renin-angiotensin-aldosterone system (RAAS) in cirrhosis. Although the activated RAAS may have several determinants, the system is often considered a surrogate marker of effective hypovolaemia. In this study we investigated the activity of the RAAS and its potential determinants with special focus on the central and arterial blood volume (CBV). Eighty-nine patients (Child class A/B/C: 19/41/29) and 32 controls were included in the study. All were given a haemodynamic examination with measurement of determinants of the RAAS, including the CBV. Circulating plasma renin concentrations were measured using an immunoradiometric assay. Arterial renin concentrations were significantly higher in the patients than in the controls (p < 0.003). Plasma renin correlated significantly with several indicators of liver dysfunction and splanchnic and systemic haemodynamics (r = - 0.56-0.55), but only weakly with CBV (r = - 0.25, p < 0.02). In a multivariate regression analysis, plasma renin was determined by serum sodium, alkaline phosphatases and systolic blood pressure (p < 0.04 to p < 0.001). CBV correlates weakly with circulating renin, and activation of the RAAS can therefore only partly be consi...Continue Reading

References

Feb 1, 1979·European Journal of Clinical Investigation·V ArroyoJ Rodes
Dec 1, 1989·Gastroenterology·J H HenriksenH Ring-Larsen
Sep 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R W SchrierJ Rodés
Jan 1, 1996·Perspectives in Biology and Medicine·A R Michell
Aug 29, 1998·Journal of Hepatology·J H HenriksenN J Christensen
Nov 18, 1998·Scandinavian Journal of Clinical and Laboratory Investigation·S Møller, J H Henriksen
Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A W SchneiderC P Klein
Mar 14, 2001·Seminars in Nephrology·R W SchrierM A Cadnapaphornchai
Oct 30, 2001·Scandinavian Journal of Clinical and Laboratory Investigation·S MøllerJ H Henriksen
Feb 28, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Søren MøllerFlemming Bendtsen
Jun 24, 2003·The American Journal of Gastroenterology·Binay K DeSanjay Dasgupta
Apr 16, 2004·The New England Journal of Medicine·Pere GinèsJuan Rodés
Sep 1, 2004·Alimentary Pharmacology & Therapeutics·S Møller, J H Henriksen

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Citations

Apr 9, 2008·Critical Care : the Official Journal of the Critical Care Forum·Rajeshwar P Mookerjee, Rajiv Jalan
Jan 16, 2009·Scandinavian Cardiovascular Journal : SCJ·Jens H Henriksen, Søren Møller
Jun 16, 2009·European Journal of Clinical Investigation·M HennenbergT Sauerbruch
Jul 13, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Pia AfzeliusSøren Møller
Apr 18, 2015·Scandinavian Journal of Gastroenterology·Søren Møller, Flemming Bendtsen
Apr 15, 2016·Heart Failure Reviews·Søren MøllerJens D Hove
May 14, 2010·Journal of Hepatology·Søren Møller, Jens H Henriksen
Apr 19, 2017·Scandinavian Journal of Clinical and Laboratory Investigation·Annette Dam FiallaAleksander Krag
Sep 19, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Søren Møller, Flemming Bendtsen
Jun 29, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jens H Henriksen
Jul 10, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Søren MøllerFlemming Bendtsen
Sep 29, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Søren MøllerJan L Madsen
Sep 19, 2019·World Journal of Gastroenterology : WJG·Ieva StundieneJonas Valantinas
Jul 24, 2020·Blood Pressure Monitoring·Pedro Augusto de C MiraMateus C Laterza

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