Determinants of the Very Low-Birth-Weight Infant's Intestinal Microbiome: A Systematic Review.

The Journal of Perinatal & Neonatal Nursing
Katelyn Desorcy-SchererLeslie A Parker

Abstract

The intestinal microbiome is the genetic material from microorganisms residing in the intestinal tract. Very low-birth-weight infants (VLBW; birth weight ≤1500 g) are a physiologically compromised population undergoing a unique period of initial intestinal microbiome establishment. Evidence supports a connection between the intestinal microbiome and gastrointestinal illness that disproportionately affects VLBW infants. Necrotizing enterocolitis, an inflammatory and often necrotic condition of the intestine, and late-onset sepsis, a bloodstream infection occurring after 3 days of life, are thought to be associated with delayed or abnormal intestinal microbiome development. Here, we review the determinants, or factors, that influence the VLBW infant's intestinal microbiome and discuss clinical implications. PubMed, Web of Science, EMBASE, and CINAHL were systematically searched for publications addressing factors with the potential to affect the intestinal microbiome of VLBW infants. Results indicate that infant's age and weight, mode of delivery, antibiotic exposure, medication use, feeding regime, environment, and perinatal-/infant-associated factors may be important determinants of the microbiome in this vulnerable population....Continue Reading

References

Feb 1, 1979·Journal of Pediatric Surgery·M J BellT Brotherton
Apr 22, 1999·Archives of Disease in Childhood. Fetal and Neonatal Edition·I H GewolbP Panigrahi
Sep 27, 2003·Seminars in Perinatology·Barbara J Stoll, Nellie Hansen
Dec 20, 2003·Gut·C P TamboliJ F Colombel
Feb 3, 2005·Pediatrics·Lawrence M GartnerUNKNOWN American Academy of Pediatrics Section on Breastfeeding
Feb 10, 2006·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Laura Beth ChamberlainAnne Merewood
Apr 7, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·R BradfordM Deighton
Oct 19, 2007·Nature·Peter J TurnbaughJeffrey I Gordon
Nov 29, 2007·The Pediatric Infectious Disease Journal·Philip L GrahamLisa Saiman
Jun 16, 2009·Journal of Pediatric Surgery·Shimae Cross FitzgibbonsTom Jaksic
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Aug 14, 2009·Acta Paediatrica·Markus V BjörkströmMagnus Domellöf
Jun 23, 2010·Proceedings of the National Academy of Sciences of the United States of America·Maria G Dominguez-BelloRob Knight
Oct 22, 2010·The Journal of Pediatrics·Aurelien JacquotJean-Charles Picaud
Jan 21, 2011·The New England Journal of Medicine·Josef Neu, W Allan Walker
May 9, 2012·Archives of Disease in Childhood. Fetal and Neonatal Edition·Juliette C MadanPatricia L Hibberd
Dec 21, 2012·Journal of Pediatric Gastroenterology and Nutrition·Raegan W GuptaDuna Penn
Dec 29, 2012·Beneficial Microbes·P V JeurinkR Martín
Feb 15, 2014·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Shehzad HudaArun Pramanik
Aug 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Patricio S La RosaPhillip I Tarr
Aug 29, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sevilay TopcuogluGuner Karatekin
Oct 22, 2014·Microbiome·Diana H TaftArdythe L Morrow
Nov 2, 2014·Indian Pediatrics·Sourabh DuttaAnil Narang
Nov 15, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Diana A ChernikovaJuliette C Madan
Feb 7, 2015·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Leslie A ParkerMartina Mueller
Apr 22, 2015·Pediatrics·Joseph SchulmanJeffrey B Gould
Aug 1, 2015·Journal of Pediatric Gastroenterology and Nutrition·Aloka L PatelAli Keshavarzian
Sep 2, 2015·Pediatrics·Jill Baley, UNKNOWN COMMITTEE ON FETUS AND NEWBORN
Jan 8, 2016·Journal of Pediatric Gastroenterology and Nutrition·Marta GómezEsther Jiménez
Feb 8, 2016·Clinical Therapeutics·Timothy G ElginSteven J McElroy
May 3, 2016·International Journal of Molecular Sciences·Silvia ArboleyaMiguel Gueimonde
Jul 6, 2016·Frontiers in Microbiology·Amy O'Callaghan, Douwe van Sinderen
Aug 31, 2016·Nature Microbiology·Molly K GibsonGautam Dantas
May 27, 2017·Seminars in Perinatology·Margaret G Parker, Aloka L Patel

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