Determinants of tidal flow volume loop indices in neonates and children with and without asthma

Pediatric Pulmonology
K C Lødrup CarlsenK H Carlsen

Abstract

The tidal flow volume (TFV) loop ratios of (1) time to peak flow (tPTEF) to total expiratory time (tE) [tPTEF/tE] and (2) volume to peak flow (VPTEF) to expired volume (VE) [VPTEF/VE] are reported to decrease with age in early life, and to decrease in subjects with obstructive airways disease (OAD). However, the mechanisms behind these changes are not well known. Thus, we reanalyzed data from 24 healthy neonates (mean birthweight: 3.49 kg +/- 0.42 kg (SD)), 26 presently asymptomatic asthmatic children (age: 33 +/- 21 months), and 26 controls (age: 34 +/- 19 months) to elucidate what is responsible for the changes in these ratios in health and disease. Lung function was measured by TFV loops (SensorMedics 2600) at 1 hour of life and on the following day in the neonates, and before and after inhaled nebulized salbutamol (0.05 mg/kg) in the asthmatics and their controls. The observed decreases in mean tPTEF/tE and VPTEF/VE from 1 hour to 1 day of life (neonates) were entirely due to increased tE and VE, respectively secondary to a decrease in respiratory rate (P = 0.03). In asthmatics (young children), the decreased baseline tPTEF/tE and VPTEF/VE were due to lower tPTEF and VPTEF, with no significant differences in tE and VE in as...Continue Reading

References

Feb 1, 1992·Pediatric Pulmonology·K C LødrupK H Carlsen
Oct 27, 1988·The New England Journal of Medicine·F D MartinezL M Taussig
Mar 1, 1987·Pediatric Pulmonology·J P Mortola, M Saetta
Oct 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·P C Kosch, A R Stark
Feb 1, 1981·Thorax·M J Morris, D J Lane
Jul 1, 1995·The European Respiratory Journal·K C Lødrup CarlsenK H Carlsen
Dec 1, 1994·The European Respiratory Journal·K H Carlsen, K C Lødrup Carlsen
Nov 1, 1994·Pediatric Pulmonology·C A DezateuxM E Fletcher
Aug 1, 1994·Pediatric Pulmonology·S Mikkilineni, S England
Sep 1, 1994·The European Respiratory Journal·K C Lødrup CarlsenK H Carlsen
May 1, 1994·Pediatric Pulmonology·J R ClarkeM Silverman
Apr 1, 1994·Pediatric Pulmonology·H AstonM Silverman
Apr 1, 1996·American Journal of Respiratory and Critical Care Medicine·C K van der EntJ M Bogaard

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Citations

Apr 23, 2003·Respiratory Physiology & Neurobiology·Gerd SchmalischAndreas Patzak
Jun 5, 2007·American Journal of Respiratory and Critical Care Medicine·Nicole BeydonUNKNOWN American Thoracic Society/European Respiratory Society Working Group on Infant and Young Children Pulmonary Function Testing
Aug 27, 2014·Pediatric Pulmonology·Zoltán HantosPeter D Sly
May 21, 2010·IEEE Transactions on Bio-medical Engineering·Steffen LeonhardtVojislav Kecman
May 10, 2005·Pediatric Pulmonology·Sitthivuddhi FutrakulNuanchan Prapphal
Feb 10, 2017·The European Respiratory Journal·Leo Pekka MalmbergMika J Mäkelä
Jan 16, 2018·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Avigdor HevroniChaim Springer
Apr 22, 2020·Allergologia et immunopathologia·E KeklikianJ A Castro-Rodriguez

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