PMID: 9553982Apr 29, 1998Paper

Determinants of total and specific IgE in infants with atopic dermatitis. ETAC Study Group. Early Treatment of the Atopic Child

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology

Abstract

ETAC (Early Treatment of the Atopic Child), a multi-centre predominantly European study to investigate the potential for cetirizine to prevent the development of asthma in infants with atopic dermatitis has completed enrollment: 817 children have been randomised to 18 months' treatment with either active or placebo and a subsequent 18 months of post-treatment follow-up. Results of the therapeutic effects will not be available for some time, but the study has provided an opportunity to investigate influences on sensitization to allergens in a large cohort of 1-2 years olds with already established atopic dermatitis, resident in different countries and in different environments. The study shows that in infants with atopic dermatitis, raised serum total IgE has significantly different determinants from that a specific allergen sensitization. In infancy, increased total IgE is more affected by factors increasing risk of intercurrent infection and non-specific airway inflammation, such as environmental tobacco smoke exposure (p < 0.001) and the use of gas cookers (p = 0.02). Specific allergen sensitization as represented by detectable IgE antibodies is influenced primarily by allergen exposure. In Sweden, low level exposure to aller...Continue Reading

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Citations

May 12, 2009·Pediatric Dermatology·Elke GovaereFrans De Baets
Jan 7, 2005·Journal of Nursing Measurement·Kathleen F GaffneyAnn H Maradiegue
Jan 13, 2009·Allergy·F M de BenedictisUNKNOWN EPAAC Study Group
Apr 22, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·U WahnUNKNOWN EPAAC Study Group
Mar 5, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·John O Warner, Jill A Warner
Jul 9, 2004·The Journal of Allergy and Clinical Immunology·Carsten FlohrHywel Williams
Jul 6, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Thomas M LiVlasta Zic
Sep 12, 2000·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M C JenmalmB Björkstén
May 11, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A WolkerstorferA P Oranje
Jul 30, 2002·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·E LanneröS L Nordvall
Oct 23, 2002·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Angela SchoetzauUNKNOWN German Infant Nutritional Intervention Study Group
Oct 23, 2002·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Thomas L Diepgen, UNKNOWN Early Treatment of the Atopic Child Study Group
Jun 6, 2003·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Ramesh KurukulaaratchyS Hasan Arshad

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