PMID: 9650051Jul 3, 1998Paper

Determinants of transmission success of individual clones from mixed-clone infections of the rodent malaria parasite, Plasmodium chabaudi

International Journal for Parasitology
L H Taylor, Andrew F Read

Abstract

Interactions between malaria parasite clones within mixed infections can have a profound effect on transmission and therefore the epidemiology of the disease. However, factors which determine the relative transmission success of individual clones from mixed infections are unknown. We have used two clones of the rodent malaria Plasmodium chabaudi to investigate changes in the clonal composition of asexual parasites over the course of mixed-clone infections in mice and how these relate to the clonal composition of transmission (oocyst) populations in mosquitoes. Clonal composition was determined using monoclonal antibody analyses for the asexual blood stage populations and PCR analysis of single oocysts for the transmission populations in mosquitoes. The relative frequency of the two clones changed dramatically during the course of the infection in mice, depending on their ratio in the inoculum. The clonal composition of parasites within mosquitoes most closely resembled that in the asexual infection at the time of transmission rather than that at any point earlier in the infection. These results provide no evidence that clones increase rates of gametocytogenesis in response to competitive suppression. Most likely, transmission s...Continue Reading

Citations

Aug 24, 2013·Trends in Ecology & Evolution·Helen C LeggettMike Boots
Aug 14, 2002·Experimental Parasitology·Louise H TaylorMark E J Woolhouse
Dec 13, 2000·International Journal for Parasitology·D J Conway, C Roper
Jun 12, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·David E Arnot
Feb 19, 2002·Trends in Parasitology·Richard E L PaulVincent Robert
Oct 16, 2002·Trends in Parasitology·Frédéric ThomasFrançois Renaud
Jun 12, 2003·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·M J MackinnonA F Read
May 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jacobus C de RoodeAndrew F Read
Aug 6, 2004·Proceedings. Biological Sciences·Jacobus C de RoodeAndrew F Read
Aug 23, 2007·Proceedings. Biological Sciences·Andrew R WargoAndrew F Read
Nov 2, 2011·Malaria Journal·Patrick L SuttonOraLee H Branch
Jul 16, 2004·Malaria Journal·Arthur M TalmanVincent Robert
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Andrew F ReadSilvie Huijben
Jul 29, 2006·The American Naturalist·Lars RabergAndrew F Read
Oct 15, 2005·The American Naturalist·Jacobus C de RoodeAndrew F Read
May 25, 2007·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·R E L PaulV Robert
Aug 26, 2006·Evolution; International Journal of Organic Evolution·Andrew S BellAndrew F Read
Mar 4, 2014·Trends in Parasitology·Catherine J PerezR C Andrew Thompson
Jun 11, 2008·Evolution; International Journal of Organic Evolution·Katrina GrechAndrew F Read

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