Determinants of under-reporting of adverse drug reactions: a systematic review.

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
Elena Lopez-GonzalezAdolfo Figueiras

Abstract

A voluntary reporting system of adverse drug reactions (ADRs) is fundamental to drug safety surveillance but under-reporting is its major limitation. This bibliographic review sought to assess the influence of personal and professional characteristics on ADR reporting and to identify knowledge and attitudes associated with ADR reporting. A systematic review was conducted using the MEDLINE and EMBASE databases. We included papers that were published in English, French and Spanish, and covered a study population made up of health professionals. In each case, the following data were extracted: study population; workplace; study type; sample size; type of questionnaire; type of scale for measuring knowledge; response rate; personal and professional factors; and knowledge and attitudes (based on Inman's 'seven deadly sins') associated with reporting. Based on a search of computerized databases, we identified a total of 657 papers in MEDLINE and 973 in EMBASE. In all, the review covered 45 papers that fulfilled the inclusion criteria. Medical specialty was the professional characteristic most closely associated with under-reporting in 76% of studies involving physicians. Other factors associated with under-reporting were ignorance (o...Continue Reading

References

Nov 1, 1992·British Journal of Clinical Pharmacology·D N Bateman
Nov 1, 1991·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·L IbáñezX Carné
Jan 6, 1990·BMJ : British Medical Journal·J FeelyP O'Connor
Jul 1, 1988·Archives of Internal Medicine·A S RogersG Faich
Mar 1, 1995·British Journal of Clinical Pharmacology·K J BeltonS M Wood
Apr 1, 1995·The Annals of Pharmacotherapy·J A GeneraliS E Rosenbaum
Dec 1, 1994·The Annals of Pharmacotherapy·K K LeeJ A Critchley
Oct 1, 1996·British Journal of Clinical Pharmacology·C C SmithD G Grahame-Smith
Feb 1, 1997·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·M CosentinoG Frigo
Jul 1, 1997·British Journal of Clinical Pharmacology·P McGettiganJ Feely
Apr 29, 1998·JAMA : the Journal of the American Medical Association·J LazarouP N Corey
Dec 3, 1999·British Journal of Clinical Pharmacology·I A ElandB H Stricker
Jan 7, 2000·Irish Journal of Medical Science·D Williams, J Feely
Aug 17, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·D Sweis, I C Wong
Feb 13, 2001·British Journal of Clinical Pharmacology·C F GreenM Pirmohamed
Feb 24, 2001·European Journal of Clinical Pharmacology·M BäckströmT Nordkvist-Olsson
Dec 12, 2001·Journal of Evaluation in Clinical Practice·A FigueirasJ J Gestal-Otero
Oct 24, 2002·Journal of Clinical Epidemiology·J HasfordB Müller-Oerlinghausen
Nov 7, 2002·European Journal of Clinical Pharmacology·F PerlíkJ Petrácek
Oct 30, 2003·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Josep Maria CastelDolors Capellà
Apr 10, 2004·Pharmacoepidemiology and Drug Safety·P Tubert-BitterC Hagry
Jul 23, 2004·Pharmacoepidemiology and Drug Safety·Kees van GrootheestLolkje de Jong-van den Berg
Oct 16, 2004·Journal of Evaluation in Clinical Practice·María T HerdeiroAdolfo Figueiras
Mar 26, 2005·Thérapie·Kolia MilojevicYves Lambert
Aug 27, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Maria T HerdeiroJuan Jesus Gestal-Otero
Nov 25, 2005·British Journal of Clinical Pharmacology·A VallanoJ M Arnau
Jan 18, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Joel Lexchin
Mar 30, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Maria T HerdeiroJ J Gestal-Otero
May 13, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Lorna Hazell, Saad A W Shakir
Jul 1, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Suparna ChatterjeeSouvik Ghosh
Sep 2, 2006·Pharmacoepidemiology and Drug Safety·Zoriah AzizNurul Suhaida Badarudin
Sep 6, 2006·Pharmacoepidemiology and Drug Safety·Anne G GranasAnne M Horn
Sep 7, 2006·JAMA : the Journal of the American Medical Association·Adolfo FigueirasJuan Jesus Gestal-Otero
Mar 28, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Maria T HerdeiroAdolfo Figueiras

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Citations

Feb 2, 2012·European Journal of Clinical Pharmacology·Jindrich SrbaJiri Vlcek
Jan 2, 2013·International Journal of Clinical Pharmacy·Derek StewartJames McLay
Dec 3, 2013·International Journal of Technology Assessment in Health Care·Caroline PagottoPatrícia Mastroianni
May 3, 2012·Nature Reviews. Genetics·Peter B JensenSøren Brunak
Apr 27, 2013·British Dental Journal·J YipD Brown
Aug 13, 2009·BMC Clinical Pharmacology·Kazeem A Oshikoya, Jacob O Awobusuyi
Nov 19, 2010·BMC Research Notes·Antonio VallanoJosep Maria Arnau
Jan 29, 2013·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Lisha Jenny JohnJayadevan Sreedharan
Mar 19, 2013·BMC Pharmacology & Toxicology·K C SantoshI Ralph Edwards
Jul 7, 2012·Therapeutics and Clinical Risk Management·Prerna UpadhyayaMushtaq Ahmed
Aug 11, 2011·American Journal of Pharmaceutical Education·Ramadan Mohamed ElkalmiMuhammad Abdul Hadi
Jun 26, 2013·International Journal of Medical Sciences·Toshiyuki SakaedaYasushi Okuno
Jul 27, 2010·European Journal of Clinical Pharmacology·Florence van HunselKees van Grootheest
Apr 20, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Mitsutaka TakadaKouichi Hosomi
Sep 1, 2012·International Journal of Clinical Pharmacy·Sílvia Isabel dos Santos PernasAdolfo Figueiras
Mar 26, 2014·Theoretical Biology & Medical Modelling·Ola CasterI Ralph Edwards
Sep 6, 2014·International Journal of Clinical Pharmacy·Stephane Steurbaut, Yolande Hanssens
Sep 27, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Keith B HoffmanColin B Erdman
Nov 26, 2014·Journal of Pharmacology & Pharmacotherapeutics·Raghava Sharma, Adithi Kellarai
Jul 14, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Maria Teresa HerdeiroAdolfo Figueiras
Jan 1, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Fabio SalviAntonio Cherubini
Mar 12, 2013·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Roberto LeoneGiampaolo Velo
Apr 13, 2013·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Lassane KaboreFrançoise Haramburu
May 4, 2013·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Cristian Gonzalez-GonzalezAdolfo Figueiras
Nov 19, 2010·Postgraduate Medicine·Richard PushkinStephanie Kim
Sep 17, 2014·Expert Review of Clinical Pharmacology·Daniel B HawcuttMark A Turner
Mar 17, 2011·Expert Opinion on Drug Safety·Anthony GrossoAroon D Hingorani
Apr 20, 2010·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Mireille GonyHaleh Bagheri
Aug 13, 2011·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Roald GerritsenEugène van Puijenbroek
Jul 15, 2011·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Bruce Hugman
Aug 1, 2015·Research in Social & Administrative Pharmacy : RSAP·Y M HopfC Bond
May 11, 2011·Journal of the American Pharmacists Association : JAPhA·Paul GavazaMary Steinhardt
Oct 2, 2012·Journal of the American Pharmacists Association : JAPhA·Paul GavazaJames P Wilson
Nov 30, 2010·Research in Social & Administrative Pharmacy : RSAP·Karine Wabø RuudElse-Lydia Toverud
Jan 26, 2013·The Journal of Sexual Medicine·Arthur L BurnettMichael G Miller
Jan 1, 2014·Sexual Medicine Reviews·Michael S Irwig
Dec 19, 2015·Annales pharmaceutiques françaises·P Joret-DescoutS Prot-Labarthe

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