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Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia

Arteriosclerosis, Thrombosis, and Vascular Biology

May 23, 2001

F H O'NeillR P Naoumova

PMID: 11348882

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Abstract

Interindividual variability in low density lipoprotein (LDL) cholesterol (LDL-C) response during treatment with statins is well documented but poorly understood. To investigate potential metabolic and genetic determinants of statin responsiveness, 19 patients with refractory heterozygou...read more

Mentioned in this Paper

Metabolic Process, Cellular
cholest-4-en-3-one
Heptanoic Acids
Cholesterol Biosynthetic Process
Hypercholesterolemia, Familial
LDL Receptor Activity
Hydroxymethylglutaryl-CoA reductase
Mevalonic Acid
Cholestenones
Bile Acid Sequestrant [EPC]
Paper Details
References
  • References31
  • Citations24
1234
  • References31
  • Citations24
123

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Determinants of variable response to statin treatment in patients with refractory familial hypercholesterolemia

Arteriosclerosis, Thrombosis, and Vascular Biology

May 23, 2001

F H O'NeillR P Naoumova

PMID: 11348882

DOI:

Abstract

Interindividual variability in low density lipoprotein (LDL) cholesterol (LDL-C) response during treatment with statins is well documented but poorly understood. To investigate potential metabolic and genetic determinants of statin responsiveness, 19 patients with refractory heterozygou...read more

Mentioned in this Paper

Metabolic Process, Cellular
cholest-4-en-3-one
Heptanoic Acids
Cholesterol Biosynthetic Process
Hypercholesterolemia, Familial
LDL Receptor Activity
Hydroxymethylglutaryl-CoA reductase
Mevalonic Acid
Cholestenones
Bile Acid Sequestrant [EPC]

Feeds With Similar Papers

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Cholesterol Synthesis & Signaling

Cholesterol is essential for a variety of cellular processes, including cell growth and division, and it plays an important role in various signaling pathways. Here is the latest research on cholesterol synthesis and the role of cholesterol in cell signaling.

Related Papers

American Journal of Ophthalmology

Corneal arcus is a sign of cardiovascular disease, even in low-risk persons(opens in new tab)

American Journal of OphthalmologyJuly 12, 2011
Marcus AngTien Yin Wong
Paper Details
References
  • References31
  • Citations24
1234
  • References31
  • Citations24
123

Download from

PubMed
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