Determinants of Virologic Failure Among Adults on Second Line Antiretroviral Therapy in Wollo, Amhara Regional State, Northeast Ethiopia

HIV/AIDS : Research and Palliative Care
Ali SeidKemal Ahmed

Abstract

Treatment failure among the population on second line antiretroviral therapy is a major public health threat. In Ethiopia there has been limited research done on second line treatment failure. To identify determinants of virologic failure among adults on second line antiretroviral therapy in six public hospitals of Wollo, Amhara regional state, northeast Ethiopia. An institution-based unmatched case-control study was conducted from February 1, 2020 to April 30, 2020 on a total of 377 clients in six public hospitals of Wollo, Amhara regional state, northeast Ethiopia. Clients whose viral load result >1,000 copies/mL in two consecutive results at least 3 month apart were cases, while ≤1,000 copies/mL were controls. The sample size was calculated by using Epi-Info version 7. Cases (94) and controls (283) were selected using a simple random sampling method in a ratio of cases-to-controls of 1:3. The model fitted and binary logistic assumptions were fulfilled with 95% confidence level and P-values<0.05 were taken as statistically significant. Virologic failure was predicted by poor adherence (AOR=6.060, 95% CI=2.837-12.944), not disclosing their HIV status (AOR=4.178, 95% CI=1.431-12.198), OI (AOR=4.11, 95% CI=1.827-9.246), CD4 coun...Continue Reading

References

Mar 24, 2018·Southern African Journal of HIV Medicine·Denver Narainsamy, Saajida Mahomed
Jan 5, 2019·BMC Infectious Diseases·Annelies Van Den HeuvelTania Crucitti

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Software Mentioned

Statistical Package for Social Science ( SPSS )
EPI
data
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