Determination and regulation of hepatotoxic pyrrolizidine alkaloids in food: A critical review of recent research

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Chuanhui MaTao Yi

Abstract

Pyrrolizidine alkaloids (PAs) are secondary metabolites of plants. PAs have been reported to be hepatotoxic, mutagenic, and carcinogenic; they are a significant group of natural toxins affecting livestock, wildlife, and humans. To date, over 10,000 PAs poisoning cases have been reported worldwide. In recent years, many articles have reported the detection of PAs in various foods, including honey, milk, meat, eggs, tea and salad. This review summarized the contamination of PAs in foods, state of the art detection methods and regulations by different countries and authorities, hoping to propose effective solutions to minimize the consumption of PAs in food.

Citations

Jun 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bahare SalehiNatália Martins
May 15, 2020·Food Additives & Contaminants. Part B, Surveillance·Vijayakumar BommurajJakob A Shimshoni
Feb 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia CasadoIsabel Sierra
Mar 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Li-Hua ChenJian-Yong Si
Sep 30, 2020·Journal of Separation Science·Fausto PradaJairo René Martínez
Nov 21, 2020·Food Chemistry·Patricia BrugnerottoAna Carolina Oliveira Costa
Jul 21, 2020·Toxicon : Official Journal of the International Society on Toxinology·Fen XiongZhengtao Wang
Jul 6, 2021·Journal of Clinical and Translational Hepatology·Wei ZhangYuzheng Zhuge
Jul 16, 2021·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Andressa Camargo ValeseAna Carolina Oliveira Costa
Sep 29, 2021·Reviews on Environmental Health·Nur Azra M PauziRozaini Abdullah

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