Determination of 4-chloroaniline and its derivatives formed in the interaction of sodium hypochlorite and chlorhexidine by using gas chromatography

Journal of Endodontics
Bettina BasraniRana N S Sodhi

Abstract

The combination of sodium hypochlorite (NaOCl) and chlorhexidine (CHX) results in the formation of a precipitate. In a previous study, we demonstrated the formation of 4-chloroaniline (PCA) in the precipitate by using x-ray photon spectroscopy (XPS) and time of flight secondary ion mass spectrometry (TOF-SIMS). The TOF-SIMS results showed a peak at 127 amu, which is characteristic of 4-chloroaniline. However, this could also be characteristic of other isomers of 4-chloroaniline such as 2-chloroaniline and 3-chloroaniline. The aim of this study was to further identify the precipitate by using gas chromatography-mass spectrometry (GC-MS). The results showed an absence of other aniline derivatives in the precipitate. Only PCA was found. Further investigations of the precipitate should address the bioavailability of PCA leaching out from dentin and its cytotoxicity. Until the precipitate is studied further, it would appear prudent to minimize its formation by avoiding the use of CHX together with NaOCl.

Citations

Feb 3, 2016·Journal of Endodontics·Ekim Onur OrhanBekir Karabucak
Mar 26, 2013·Journal of Endodontics·Maíra PradoBrenda P F A Gomes
Dec 14, 2011·Journal of Endodontics·Hyeon-Sik KimKee-Yeon Kum
May 23, 2014·Acta Odontologica Scandinavica·Samuel Henrique Câmara De BemJesus Djalma Pécora
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Dec 9, 2020·Clinical and Experimental Dental Research·Brian MinaviRansome van der Hoeven
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Barbara CzopikMichał Woźniakiewicz
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