PMID: 9428598Jan 15, 1998Paper

Determination of 5-hydroxy-L-[beta-11C]tryptophan and its in vivo-formed radiolabeled metabolites in brain tissue using high performance liquid chromatography: a study supporting radiotracer kinetics obtained with positron emission tomography

Nuclear Medicine and Biology
K J LindnerB Långström

Abstract

A high performance liquid chromatographic system was developed for separation of 11C-labeled 5-hydroxy-L-tryptophan ([11C]HTP) and in vivo formed radiolabeled metabolites in rat brain tissue. Analysis of brain homogenate revealed that the main part of the radioactivity was associated with 11C-labeled 5-hydroxyindole-3-acetic acid after intravenous injection of [11C]HTP to the rat. The serotonin synthesis rate in the brain was calculated and closely correlated to the serotonin synthesis rate in monkey and human measured using positron emission tomography.

References

Feb 1, 1978·British Journal of Pharmacology·J L Gordon, H J Olverman
Jan 1, 1991·Journal of Neural Transmission. General Section·P HartvigB Långström
Apr 1, 1989·Journal of Hypertension·H D ItskovitzC T Stier
Sep 15, 1994·Annals of the New York Academy of Sciences·B ErikssonK Oberg

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Citations

Nov 30, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Anniek K D VisserRudi A J O Dierckx
Oct 3, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anniek K D VisserAren van Waarde
Aug 10, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Pinelopi LundquistBengt Långström
Nov 20, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Gisela E HagbergGunnar Blomqvist
May 22, 2004·Annals of the New York Academy of Sciences·Anders SundinHåkan Orlefors
Feb 17, 2009·Journal of Avian Medicine and Surgery·Erik StauberJohn Hall
Sep 25, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Valentina Di GialleonardoErik F J de Vries

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