Determination of acid dissociation constants and reaction kinetics of dimethylamine-based PPCPs with O3 , NaClO, ClO2 and KMnO4

Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
Xiaofeng WangXia Shao

Abstract

Dimethylamine-based pharmaceutical personal care products (DMA-based PPCPs) are a group of N-nitrosodimethylamine (NDMA) precursors. The acid dissociation constant (pKa) values of four DMA-based PPCPs were determined by potentiometric titration over the pH range of 3-11. The pKa values of ranitidine, nizatidine, doxylamine and carbinoxamine corresponding to the DMA moiety were 8.4, 6.8, 9.4 and 9.1, respectively. Competition reaction kinetics and pseudo-first-order reaction kinetics were used to determine the reaction rate constant (k) of the DMA-based PPCPs with O3, NaClO, ClO2 and KMnO4. Comparing the degradation rate constants of the four DMA-based PPCPs, the results of ClO2 oxidation were close, and for the other three oxidants, the order was kranitidine ≈ knizatidine > kdoxylamine ≈ kcarbinoxamine. Comparing the reaction rate of the four oxidants, for ranitidine and nizatidine, the order was kNaClO > kO3 > kKMnO4 > kClO2, and for doxylamine and carbinoxamine, the order was kO3 > kNaClO > kClO2 > kKMnO4.

References

Mar 30, 2004·Environmental Science & Technology·William A Mitch, David L Sedlak
May 12, 2009·Chemosphere·Javier RivasFernando Beltrán
Jan 5, 2012·Environmental Science & Technology·Julien Le RouxJean-Philippe Croué
Aug 24, 2016·Journal of Environmental Management·Jianlong Wang, Shizong Wang
Mar 2, 2018·Environmental Science and Pollution Research International·Rusen ZouBaoling Yuan
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