PMID: 2100222Jan 1, 1990Paper

Determination of albuterol concentrations in human plasma using solid-phase extraction and high-performance liquid chromatography with fluorescence detection

Journal of Pharmaceutical and Biomedical Analysis
R E BlandJ R Powell

Abstract

A fast, simple, and accurate method for determining albuterol concentrations in human plasma has been developed and validated for use in routine clinical analyses. This method involves a solid-phase extraction procedure using silica cartridges and normal-phase high-performance liquid chromatography with fluorescence detection. Regression analysis showed the method was linear over the standard curve range 1-16 ng ml-1. The percent recovery for albuterol and the internal standard, bamethane, at 5 ng ml-1 was found to be greater than 90%. The newly developed method has been applied in the analysis of plasma samples from patients and healthy volunteers.

Citations

Jan 1, 1996·Clinical Reviews in Allergy & Immunology·D W Boulton, J P Fawcett
Apr 1, 1994·Journal of Chromatography. B, Biomedical Applications·R N GuptaM B Dolovich
Oct 6, 1995·Journal of Chromatography. B, Biomedical Applications·D W Boulton, J P Fawcett
Jan 1, 1995·The American Journal of Emergency Medicine·C Rodrigo, G Rodrigo
May 9, 1997·Journal of Chromatography. B, Biomedical Sciences and Applications·T W LogsdonC M Compadre
Mar 18, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·R BergésR Ventura
Jan 1, 1996·British Journal of Clinical Pharmacology·D W Boulton, J P Fawcett
Mar 1, 1996·The American Journal of Emergency Medicine·G Rodrigo, C Rodrigo
Nov 25, 1998·The American Journal of Emergency Medicine·C Rodrigo, G Rodrigo
May 19, 2000·Archiv der Pharmazie·H Y Aboul-Enein, M Surmeian

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