PMID: 2490559Jan 1, 1989Paper

Determination of aminoglycosides in pharmaceutical formulations--II. High-performance liquid chromatography

Journal of Pharmaceutical and Biomedical Analysis
H FabreB Mandrou

Abstract

A post-column derivatization procedure using OPA and fluorescence detection has been used for the determination of seven aminoglycosides (dibekacin, framycetin, kanamycin, netilmicin, sisomicin, tobramycin and gentamicin) in commercial pharmaceutical formulations. The linearity, precision and detection limits were satisfactory. Recoveries from eye drops, ointments, injections and capsules were comparable (P = 0.05) to those obtained with TLC or microbiological assays. A ruggedness test showed that the method was not sensitive to minor variations in the mobile phase composition, post-column derivatization system or detection wavelength.

References

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Citations

Apr 11, 2006·Analytical and Bioanalytical Chemistry·Nan SunZhenlu Shen
Jun 20, 2013·Journal of Materials Science. Materials in Medicine·Mirjam LiljaMaria Strømme
Jul 1, 1995·Journal of Pharmaceutical and Biomedical Analysis·M SantosA Domínguez-Gil
Oct 7, 2000·Journal of Pharmaceutical and Biomedical Analysis·J SzúnyogJ Hoogmartens
Oct 22, 2011·Journal of Pharmaceutical and Biomedical Analysis·Mohamed Nouri El-AttugAnn Van Schepdael
Mar 30, 2010·Journal of Pharmaceutical and Biomedical Analysis·Shruti ChopraErwin Adams
Mar 23, 2013·Luminescence : the Journal of Biological and Chemical Luminescence·Serife Evrim Kepekci TekkeliA Olcay Sağırlı
Mar 29, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jan Henrik SörensenHartwig Steckel
Feb 24, 2015·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Hytham M Ahmed, Wael B Ebeid
Aug 14, 2019·Journal of Biomaterials Applications·Oscar JansonKen Welch
Jun 12, 2020·Veterinary Ophthalmology·Alex B SigmundDiane V H Hendrix
Oct 15, 2008·Rapid Communications in Mass Spectrometry : RCM·Bo LiErwin Adams

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Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

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Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.